I-Hydroxypropyl methylcellulose (HPMC)i-sonthetic cellulose etholwa kanye ne-polymer ye-polymer ye-semi-zokwenziwa. Kusetshenziswa kabanzi kwizimboni eziningi ezinjengezokwakha, umuthi, ukudla, izimonyo nezimbobo. Njenge-ether ye-cellulose engeyona eye-ionic, i-HPMC ine-solubility yamanzi enhle, izakhiwo ezakha amafilimu, ukunamathela kanye nokusizakala, ngakho-ke inenani lesicelo elibalulekile emikhakheni eminingi.
1. Isakhiwo samakhemikhali nezakhiwo ze-HPMC
Ukwakheka kwamangqamuzana kwe-HPMC kususelwa ku-cellulose yemvelo. Ngemuva kokuguqulwa kwamakhemikhali, i-methyl (--Och₃) ne-hydroxypropyls (-Och₂chroh) amaqembu angeniswa ecaleni le-cellulose. Isakhiwo saso samakhemikhali asisekelo simi ngokulandelayo:
Ama-molecule we-cellulose akhiwa ama-glucose amayunithi axhunywe ngamabhondi angu-β-1,4-glycosidic;
Amaqembu we-methyl kanye ne-hydroxypropyl angeniswa ecaleni le-cellulose ngokushintshana kokunye.
Lesi sakhiwo samakhemikhali sinikeza i-HPMC izakhiwo ezilandelayo:
I-Solubinity yamanzi: Ngokulawula izinga lokufaka esikhundleni se-methyl namaqembu we-hpddypropyl, i-HPMC ingalungisa i-solubity yayo yamanzi. Ngokuvamile, i-HPMC ingakha isixazululo esibonakalayo emanzini abandayo futhi ine-solubility enhle yamanzi.
Ukulungiswa kwe-Viscosity: I-viscosity ye-HPMC ingalawulwa ngokunembile ngokulungisa isisindo samangqamuzana kanye nezinga lokufaka esikhundleni sokuhlangabezana nezidingo ezihlukile zohlelo lokusebenza.
Ukumelana nokushisa: Njengoba i-HPMC iyinto ye-Thermoplastic polymer, ukumelana kwayo kukuhle kakhulu futhi kungagcina ukusebenza okuzinzile ngaphakathi ebangeni elithile lokushisa.
I-BioCOMTIBIfo: I-HPMC iyinto engeyona enobuthi futhi engacasuli, ngakho-ke ithandeke kakhulu emkhakheni wezokwelapha.
2. Ukulungiselela Indlela ye-HPMC
Indlela yokulungiselela i-HPMC iphothulwa kakhulu ukusabela kokuhlonza kweselula. Izinyathelo ezithile zinjengokulandelayo:
Ukuqothulwa kwe-Cellulose: Okokuqala, hlanganisa i-cellulose yemvelo nge-solvent (efana ne-chloroform, i-solicol solvent, njll.) Ukuyikhipha kusixazululo se-cellulose.
Ukuguqulwa kwamakhemikhali: amakhemikhali wamakhemikhali we-methylypropyllyl (anjenge-chloromethyl
Ukungathathi hlangothi nokomisa: Inani le-PH liyalungiswa ngokungeza i-acid noma i-alkali, futhi ukuhlukaniswa, ukuhlinza kwenziwa ngemuva kokusabela ekugcineni kwe-hydroxypropylyllylylylyl.
3. Ukusetshenziswa okuyinhloko kwe-HPMC
Izakhiwo ezihlukile ze-HPMC zenza ukuthi zisetshenziswe kabanzi emikhakheni eminingi. Okulandelayo ezinye zezindawo eziphambili zohlelo:
(1) Inkambu Yokwakha: I-HPMC isetshenziswa kabanzi embonini yezokwakha, ikakhulukazi ezakhiweni zokwakha ezinjengesimende, udaka nodaka kanye nokumbona. Kungathuthukisa uketshezi, ukunamathela nokugcinwa kwamanzi kwengxube. Ikakhulu kuDonsi elomile, i-HPMC ingathuthukisa ukusebenza kokwakha, yandise ukunqwabelana kodaka, futhi igweme imifantu ku-slurry kasimende ngesikhathi senqubo enzima.
(2) Inkambu yezemithi: Ensimini yezemithi, i-HPMC ivame ukusetshenziselwa ukupheka amaphilisi, amaphilisi kanye nezidakamizwa eziwuketshezi. Njengomenzeli owakha amafilimu, umkhulu kanye ne-stabilizer, kungathuthukisa i-solubity kanye nokuvulula kwezidakamizwa. Kumathebulethi, i-HPMC ayikwazi ukulawula kuphela isilinganiso sokukhishwa kwezidakamizwa, kepha futhi ithuthukisa ukuqina kwezidakamizwa.
(3) Inkambu yokudla: I-HPMC ingasetshenziswa ekusebenzeni kokudla njengoMkhulu, i-Emulsifier neStabilizer. Isibonelo, ekudleni okunamafutha aphansi nangamafutha, i-HPMC inganikeza ukunambitheka okungcono nokuthungwa futhi yandise ukuqina komkhiqizo. Iphinde isetshenziswe kabanzi ekudleni eqandisiwe ukuvikela ukwahlukaniswa kwamanzi noma ukwakheka kwe-ice crystal.
(4) Izimonyo: Izimonyo, i-HPMC ivame ukusetshenziswa njenge-mkhulu, i-emulsifier kanye ne-moisturizer. Kungathuthukisa ukuthungwa kwezimonyo, okwenza kube lula ukusebenzisa futhi bamunca. Ikakhulu kumakhilimu wesikhumba, ama-shampoos, imaski yobuso neminye imikhiqizo, ukusetshenziswa kwe-HPMC kungathuthukisa umuzwa nokuqina komkhiqizo.
. Kungathuthukisa futhi ukumelana kwamanzi kanye nezakhiwo ezilwa nama-coating, futhi kwandise ubulukhuni kanye nokunamathela kwe-coating.
4. Amathemba emakethe kanye nezitayela zentuthuko ze-HPMC
Njengoba abantu benaka ngokwengeziwe nokutholwa okwengeziwe ekuvikelweni kwemvelo kanye nezempilo, i-HPMC, njengezinto eziluhlaza futhi ezingezona ezinobuthi be-polymer, zinamathuba abanzi. Ikakhulu emikhakheni yezemithi, yokudla kanye nezimonyo, ukusetshenziswa kwe-HPMC kuzokwandiswa okwengeziwe. Esikhathini esizayo, inqubo yokukhiqiza ye-HPMC kungenzeka isetshenziswe ngokwengeziwe, futhi ukwanda kokukhishwa kanye nokwehliswa kwezindleko kuzothuthukisa uhlelo lwayo ezimbonini eziningi.
Ngokuthuthukiswa kwezinto ezihlakaniphile ze-Smart kanye nobuchwepheshe bokukhishwa okulawulwayo, ukusetshenziswa kwe-HPMC ezinhlelweni ze-Smart Drug Delivery kuzobuye kube yi-hotspot ecwaningayo. Isibonelo, i-HPMC ingasetshenziswa ukulungiselela izidakamizwa ezinomsebenzi wokukhishwa alawulwa ukwandisa isikhathi somphumela wezidakamizwa futhi uthuthukise ukusebenza kahle.
Hydroxypropyl methylcelluloseIngabe impahla ye-polymer esebenza kahle kakhulu nohlelo olubanzi. Ngamandla alo amahle e-solubility, amandla okuguqula i-viocosity kanye ne-biocomtic enhle, i-HPMC inezicelo ezibalulekile emikhakheni eminingi efana nokwakha, umuthi, izinkambu zokukhiqiza ze-HPMC zingaqhubeka ukunwebeka, futhi amathuba okuthuthuka azayo abanzi kakhulu.
Isikhathi sePosi: Mar-11-2025