Cwaninga ekusetshenzisweni kwe-HEC kumalungiselelo emithi

I-HEC (HYDROXYETHY Cellulose)i-polymer evamile enamanzi esetshenziswe kabanzi kumalungiselelo emithi. Kuyinto etholwa yi-cellulose, etholwe ngokuphendula i-ethanolamine (ethylene oxide) nge-cellulose. Ngenxa ye-solubility yayo enhle, ukuqina, ukuqina kwekhono lokulungiswa kanye nokuqina kwezicelo, i-HEC inezinhlobonhlobo zezicelo enkundleni yezemithi, ikakhulukazi ekuthuthukisweni kokwakhiwa, ukwamukelwa kwezidakamizwa kwezidakamizwa kanye nokulawulwa kwezidakamizwa kwezidakamizwa.

1. Izici eziyisisekelo ze-HEC
I-HEC, njenge-cellulose eguquliwe, inezakhiwo eziyisisekelo ezilandelayo:

I-Solubinity yamanzi: ICICCENCKHEC ingakha isixazululo esibonakalayo emanzini, futhi ukulekelela kwayo kuhlobene nokushisa kanye no-pH. Le mpahla yenza ukuthi isetshenziswe ezinhlobonhlobo zamadosamu ahlukahlukene anjenge-oral ne-topical.

I-BioCOMTILibility: I-HEC ayinobuthi futhi ayicasuli emzimbeni womuntu futhi iyahambelana nezidakamizwa eziningi. Ngakho-ke, kusetshenziswa kabanzi amafomu umthamo wamadosi wokukhishwa okugciniwe kanye nezindlela zokuphatha zendawo zokuphatha.

I-Viscosity Eguquguqukayo: I-Viscosity ye-HEC ingashintshwa ngokushintsha isisindo sayo samangqamuzana noma okuhlushwa, okubaluleke kakhulu ukulawula isilinganiso sezidakamizwa noma ukwenza ngcono ukuqina kwezidakamizwa noma ukwenza ngcono ukuqina kwezidakamizwa.

2. Ukusetshenziswa kwe-HEC kumalungiselelo wezemithi
Njengomuntu obalulekile e-Execipient kumalungiselelo emithi, i-HEC inemisebenzi eminingi. Okulandelayo yizindawo zayo eziphambili zohlelo lokusebenza kumalungiselelo emithi.

2.1 Isicelo kumalungiselelo omlomo
Ezinhlelweni zomthamo ngomlomo, i-HEC ivame ukusetshenziselwa ukukhiqizwa kwamathebulethi, amaphilisi kanye namalungiselelo e-liquid. Imisebenzi yayo eyinhloko ifaka phakathi:

I-Binder: Kumathebulethi kanye nama-granules, i-HEC ingasetshenziswa njenge-tinder yokubopha kangcono izinhlayiya zezidakamizwa noma i-powders ndawonye ukuqinisekisa ubulukhuni nokuqina kwamathebulethi.
Ukulawulwa kokukhishwa okuqhubekayo: I-HEC ingafinyelela umphumela wokukhishwa okuqhubekayo ngokulawula isilinganiso sokukhishwa kwesidakamizwa. Lapho i-HEC isetshenziswa kanye nezinye izithako (njenge-polyvinyl pyrlolidone, i-carboxymethyl cellulose, njll.
I-Shirener: Kumalungiselelo omlomo aketshezi, i-coxinchel ®hec njengomuntu omkhulu angathuthukisa ukunambitheka kwesidakamizwa kanye nokuqina kwefomu lomthamo.

2.2 Isicelo kumalungiselelo aphezulu
I-HEC isetshenziswa kabanzi kuma-oriorements aphezulu, okhilimu, ama-gels, ama-lotion kanye namanye amalungiselelo, ukudlala izindima eziningi:

I-Gel Matrix: I-HEC ivame ukusetshenziswa njenge-matrix yama-gels, ikakhulukazi ezinhlelweni zokulethwa kwezidakamizwa. Inganikeza ukuvumelana okufanelekile futhi yandise isikhathi sokuhlala somuthi esikhunjeni, ngaleyo ndlela sithuthukise ukusebenza kahle.
I-Viscosity Nokuqina: I-Viscosity ye-HEC ingathuthukisa ukunamathela kwamalungiselelo aphezulu esikhunjeni futhi ivikele isidakamizwa ukuthi ingabiki ngaphambi kwesikhathi ngenxa yezici ezinjengengxabano noma ukugeza. Ngaphezu kwalokho, i-HEC ingathuthukisa ukuqina kokhilimu kanye namafutha okugcoba nokuvimbela ukuhlukaniswa noma i-crystallization.
I-Lubrant ne-moisturizer: I-HEC inezakhiwo ezinhle kakhulu zokuswakama futhi ingasiza ukugcina isikhumba simanzile futhi sivikele ukoma, ngakho-ke kusetshenziswa futhi kuma-moisturizer neminye imikhiqizo yokunakekelwa kwesikhumba.

2.3 Isicelo kumalungiselelo we-ophthalmic
Ukusetshenziswa kwe-HEC kumalungiselelo we-ophthalmic ikakhulukazi kuboniswa endimeni yayo njengokunamathela nokuthambisa:

I-Ophthalmic Gels kanye nama-eye esweni: I-HEC ingasetshenziswa njenge-adhesive yamalungiselelo we-ophthalmic ukunweba isikhathi sokuxhumana phakathi kwesidakamizwa neso futhi uqinisekise ukusebenza kahle kwesidakamizwa. Ngasikhathi sinye, i-viscosity yayo ingavimba futhi iso lehle ekulahlekelweni ngokushesha okukhulu futhi likhulise isikhathi sokugcinwa kwesidakamizwa.
I-Lubrication: I-HEC ine-hydration enhle futhi inganikeza ngokuhlanza okuqhubekayo ekwelashweni kwezifo ze-ophthalmic ezinjengeso elomile, ukunciphisa ukungaphatheki kwamehlo.

2.4 Isicelo kumalungiselelo okujova
I-HEC nayo ingasetjenziswa lapho kulungiswa amafomu umthamo wokujova, ikakhulukazi emijondolo ethatha isikhathi eside kanye namalungiselelo wokukhulula okulondoloziwe. Imisebenzi esemqoka ye-HEC kulawa malungiselelo ifaka:

I-Shirener ne-Stabilizer: Kumjovo,I-HECIngakhuphula i-viscosity yesixazululo, yehlisa ijubane lomjovo wesidakamizwa, futhi ithuthukise ukuqina kwesidakamizwa.
Ukulawula Ukukhishwa Kwezidakamizwa: Njengenye yezinto zohlelo olugciniwe lwezidakamizwa, i-HEC ingalawula isilinganiso sokukhishwa kwesidakamizwa ngokwakha ungqimba lwe-gel ngemuva komjovo, ukuze kufezeke injongo yokwelashwa kwesikhathi eside.

3. Iqhaza le-HEC ezinhlelweni zokulethwa kwezidakamizwa
Ngokuthuthukiswa kobuchwepheshe bezemithi, i-HEC isetshenziswe kabanzi ezinhlelweni ezahlukahlukene zokulethwa kwezidakamizwa, ikakhulukazi emikhakheni yabathwali bezidakamizwa, ama-microsros, kanye nezidakamizwa ezigciniwe ngezidakamizwa. I-HEC ingahlanganiswa nezinhlobonhlobo zezinto ezithwala izidakamizwa zokwakha isakhiwo esitebele ukuqinisekisa ukukhishwa okuqhubekayo nokulethwa kwezidakamizwa okusebenzayo.

I-Nano Driar Carrier: I-HEC ingasetshenziswa njenge-stabilizer ye-nano izidakamizwa ezithwala izidakamizwa ukuvikela ukuhlanganiswa noma ukuhanjiswa kwemvula yezinhlayiya zenethiwekhi futhi kwandise ama-bioavailability of izidakamizwa.
Ama-Microsros kanye nezinhlayiya: I-HICK ingasetshenziselwa ukupheka ama-microsrones kanye ne-microparticle izidakamizwa izidakamizwa ukuqinisekisa ukukhululwa kancane kwezidakamizwa emzimbeni futhi kuthuthukise ukusebenza kwezidakamizwa.

Njenge-multifunctional and esebenza ngezemithi exepipunt, i-ComCinCel®hec inamathemba okusebenza abanzi kumalungiselelo emithi. Ngokuthuthuka okuqhubekayo kobuchwepheshe bezemithi, i-HEC idlala indima ebaluleke kakhulu ekulweni nokukhishwa kwezidakamizwa, ukuphathwa kwendawo, amalungiselelo okukhishwa kwezidakamizwa nezinhlelo ezintsha zokulethwa kwezidakamizwa. Ukuqina kwayo okuhle, i-visoluty eguqukayo nokuqina kwenza kungafinyeleleki emkhakheni wezokwelapha. Ngokuzayo, ngokutadisha okujulile kwe-HEC, uhlelo lwayo kumalungiselelo omakhamikhali luzokhulisa kakhulu futhi luhlukaniswe.