Ukuphepha kwe-HPMC ezithangekweni zokudla

1. Ukubuka konke kwe-HPMC

I-HPMC (HYDROXYPROPYL Methylcellulose) i-cellulose derivative etholwe ukuguqulwa kwamakhemikhali. Itholakala kwisitshalo semvelo se-celtulose ngokusebenzisa ukusabela kwamakhemikhali njenge-methylation ne-hydroxypropylition. I-HPMC ine-solubility enhle yamanzi, ukulungiswa kwamanzi, izakhiwo ezakha amafilimu nokuqina, ngakho-ke kusetshenziswe kabanzi ezimbonini eziningi, ikakhulukazi emikhakheni yokudla, umuthi kanye nezimonyo, njengomuntu omkhulu, isikhunta, i-emulsifier and gelling ejenti.

Embonini yokudla, i-HPMC ivame ukusetshenziswa njengomuntu omkhulu, umenzeli we-gelling, ohlekisayo, emulsifier kanye ne-stabilizer. Uhla lwayo lokusebenza ekudleni lubandakanya: Isinkwa, amakhekhe, amabhisikidi, uswidi, u-ayisikhilimu, ama-ayisikhilimu, iziphuzo, ukudla okuthe xaxa. Isizathu esibalulekile sohlelo lokusebenza lwaso olubanzi yileyohlankulu yeCefitchel®HPMC inokuqina okuhle kwamakhemikhali, akulula ukuphendula nezinye izithako, futhi kudonswa kalula ngaphansi kwezimo ezifanele.

2. Ukuhlola ukuphepha kwe-HPMC

I-HPMC iye yaqashelwa futhi yavunywa ngama-ejensi amaningi okuphepha kazwelonke nasezweni lonke njengesengezo sokudla. Ukuphepha kwayo kuhlolizwe ikakhulukazi ngezinto ezilandelayo:

Isifundo Sobuthi

Njengokutholwa kwe-cellulose, i-HPMC isuselwa kwisitshalo se-cellulose futhi inobuthi obuphansi. Ngokusho kwezifundo eziningi ze-toxicology, ukusetshenziswa kwe-HPMC ekudleni akubonisi ubuthi obubucayi noma obungapheli. Izifundo eziningi zikhombise ukuthi i-HPMC inokuthambekela okuhle futhi ngeke kubangele imiphumela enobuthi enobuthi emzimbeni womuntu. Isibonelo, imiphumela yokuhlolwa kobuthi be-acute onobuthi be-HPMC kuboniswe ukuthi akukho mvumelwano obusobala bokuvuselela ubuthi okwenzeka ngemithamo ephezulu (edlula ukusetshenziswa kwansuku zonke izengezo zokudla).

Ukudla no-Adis (okwamukelekayo nsuku zonke)

Ngokusho kokuhlolwa kochwepheshe bokuphepha kokudla, ukwamukelwa kwansuku zonke (i-ADI) ye-HPMC ngeke kulimaze impilo yabantu ngaphakathi kohlu olusebenzayo lokusetshenziswa. IKomidi Lochwepheshe Lamazwe Ngamazwe ngezithasiselo zokudla (Jecfa) kanye ne-US Food Food and Drug Administration (FDA) nezinye izikhungo babone ukuphepha kwe-HPMC njengezengezo zokudla kanye nokusetha okulinganiselwe kokudla kwayo. Ngombiko wayo wokuhlola, uJecfa waveza ukuthi i-HPMC ayikhombisanga noma yimiphi imiphumela enobuthi enobuthi, futhi ukusetshenziswa kwayo ekudleni ngokuvamile kungaphansi kwenani le-ADI elisethiwe, ngakho-ke abathengi abadingi ukukhathazeka ngezingozi zalo zezempilo.

I-allergic reactions kanye nokusabela okubi

Njengento yemvelo, i-HPMC inezigameko eziphansi kakhulu zokusabela komzimba. Iningi labantu alinawo ukusabela komzimba ku-HPMC. Kodwa-ke, abanye abantu abazwela bangathola izimpawu ezithambile ezifana nokuqhuma kanye nokufushane komoya lapho kudla ukudla okuqukethe i-HPMC. Ukusabela okunjalo kuvame ukungavamile. Uma kwenzeka ukungakhululeki, kunconywa ukuyeka ukudla ukudla okuqukethe i-HPMC futhi kufune izeluleko udokotela ochwepheshe.

Ukusetshenziswa kwesikhathi eside kanye nempilo yamathumbu

Njengengxenye ephakeme kakhulu, inhlawulo ye-FICCINCHXYPPMC kunzima ukudonswa ngumzimba womuntu, kepha ingadlala indima ethile njengefayibha yokudla emathunjini futhi ithuthukise i-Peristalsis. Ngakho-ke, ukuphuza okulinganiselwe kwe-HPMC kungaba nomthelela othile omuhle empilweni yamathumbu. Isibonelo, ezinye izifundo zikhombisile ukuthi i-HPMC inamandla athile ekwenzeni ngcono ukuqunjelwa kwamathumbu nokudambisa ukuqunjelwa. Kodwa-ke, ukungena ngokweqile kwe-HPMC kungadala ukungakhululeki kwamathumbu, ukubhekana nesisu, isifo sohudo nezinye izimpawu, ngakho-ke umgomo wokuhlolisisa kufanele ulandelwe.

3. Isimo sokuvunywa se-HPMC emazweni ahlukene

Izitsha zokudlela zebumba uqobo

E-China, i-HPMC ifakwe kuhlu njengesengezo sokudla esivunyelwe, esisetshenziswa kakhulu kuma-candies, ama-candiments, iziphuzo, imikhiqizo ye-pasta, njll. Ngokusho "okujwayelekile ngokusetshenziswa kwezithasiselo zokudla", i-HPMC ivunyelwe ukusetshenziswa ekudleni okuthile futhi kunomkhawulo wokusetshenziswa okuqinile.

iyuniyani yase-Europe

E-European Union, i-HPMC nayo yamukelwa njengesengezo sokudla esiphephile, esibaliwe e464. Ngokombiko wokuhlola we-European Food Safety Authority (EFSA), i-HPMC iphephile ngaphansi kwezimo ezicacisiwe zokusebenzisa futhi ayibonisi imiphumela emibi empilweni yabantu.

I-united states

I-US FDA ibala i-HPMC ngokuthi "yamukelwa ngokujwayelekile njengento ephephile" (GRAS) futhi ivumela ukusetshenziswa kwayo ekudleni. I-FDA ayibeki imikhawulo emqubeni eqinile yokusebenzisa i-HPMC, futhi ikakhulukazi ihlola ukuphepha kwayo ngokusekelwe kwidatha yesayensi ekusetshenzisweni kwangempela.

Njengesengezo sokudla,I-HPMC ivunyelwe emazweni amaningi nasezifundeni emhlabeni wonke futhi ibhekwa njengephephile ngaphakathi kwebanga lokusebenzisa elibekiwe. Ukuphepha kwayo kuqinisekiswe yizifundo eziningi zobuthi kanye nemikhuba yemitholampilo, futhi akubangeli ukulimala okubalulekile empilweni yabantu. Kodwa-ke, njengazo zonke izithasiselo zokudla, ukuthathwa kwe-HPMC kufanele kulandele umgomo wokusebenzisa okunengqondo futhi ugweme ukuphakanyiswa ngokweqile. Abantu abanokungezwani komzimba kufanele baqaphele lapho bedla ukudla okuqukethe i-HPMC ukunciphisa ukuvela kokuphendula okungenzeki.

I-HPMC iyisengezo esisetshenziswa kabanzi futhi esiphephile embonini yokudla, ibeka engcupheni yempilo emphakathini. Ngokuthuthuka kwesayensi nobuchwepheshe, ucwaningo kanye nokugadwa kweCexincEl®HPMC kungahle kube nzima kakhulu esikhathini esizayo ukuqinisekisa ukuphepha kwayo.