I-Solubity ye-HPMC

I-Hydroxypropyl Methylcellulose (HPMC) iyancibilika emanzini, okungenye yezakhiwo zayo ezibaluleke kakhulu futhi inomthelela ekuguquguqukeni kwayo ezinhlelweni ezahlukahlukene. Uma kungezwe emanzini, ama-HPMC asaphuphuthekayo nama-hydrate, akha izixazululo ezicacile nezibonakalayo. I-solubity ye-HPMC incike ezicini eziningana, kufaka phakathi izinga lokufaka esikhundleni (DS), isisindo samangqamuzana se-polymer, kanye nokushisa kwesisombululo.

Ngokuvamile, i-HPMC enamanani we-DS aphansi athambekele ekuncibilikisweni kwamanzi ngokuqhathaniswa ne-HPMC enamanani aphezulu we-DS. Ngokufanayo, i-HPMC enamamaki wesisindo aphansi aphansi angaba namazinga okuchithwa ngokushesha uma kuqhathaniswa namabanga aphezulu wesisindo samangqamuzana.

Izinga lokushisa lesisombululo futhi lithonya i-solubility ye-HPMC. Izinga lokushisa eliphakeme ngokujwayelekile lithuthukisa i-solubity ye-HPMC, ivumela ukuqedwa okusheshayo kanye ne-hydration. Kodwa-ke, izixazululo ze-HPMC zingabhekana nokuhlukaniswa noma ukuhlukaniswa kwesigaba emazingeni okushisa aphakeme, ikakhulukazi ekugxilisweni okuphezulu.

Kubalulekile ukuqaphela ukuthi ngenkathi i-HPMC ingena emanzini, izinga lokuchithwa kwezinga lokuchithwa kungahluka ngokuya ngebanga elithile le-HPMC, izimo ezakhiwe, nanoma yiziphi ezinye izengezo ezikhona ohlelweni. Ngokwengeziwe, i-HPMC ingabonisa izici ezihlukile ze-solubity ku-organic solvents noma ezinye izinhlelo ezingezona ezinamanzi.

I-solubity ye-HPMC emanzini yenza kube yi-polymer ebalulekile yezinhlelo zokusebenza ezahlukahlukene lapho ukuguqulwa kwe-viscosity, ukwakheka kwamafilimu, noma okunye ukusebenza kufiswa.