I-Hydroxypropyl Methylcellulose (HPMC) iyinhlangano eguquguqukayo esetshenziswa kabanzi ezimbonini ezisukela emikhakheni esuka emikhakheni ezokwakha ngenxa yezakhiwo zayo ezihlukile ngenxa yezakhiwo zayo ezihlukile. Kuyinto etholwa yi-cellulose, amaqembu e-hydroxyl afakwe esikhundleni ngamaqembu we-methoxy ne-hydroxypropyl, athuthukise i-solubity yayo emanzini nakwezinye izinto eziphilayo.
Izici ze-Solubity ze-HPMC
1. I-solubity yamanzi
I-HPMC incibilika kakhulu yamanzi. I-solubility yayo emanzini ithonywa yizici eziningana:
Ukushisa: I-HPMC iyancibilika emanzini abandayo noma egumbini lokushisa. Lapho kushisa, i-HPMC ingakha ijeli; Ekupholiseni, ijeli liphinda lincibilike, lilenze libuye libuye libuye. Le gelation eshisayo iyasebenziseka kuzinhlelo zokusebenza njengokukhishwa kwezidakamizwa okulawulwayo emikhakheni.
Ukugxila: Ukugxila okuphansi (0.5-2%) ngokuvamile kuncibilika kalula. Ukugxila okuphezulu (kuze kufike ku-10%) kungadinga ukushukumba okwengeziwe nesikhathi.
I-PH: Izixazululo ze-HPMC zizinza enanini elibanzi le-PH (3-11), zibenze baguquguquke ngezindlela ezihlukile.
2. Izixazululo ze-organic
Ngenkathi ngokuyinhloko i-mater-soluble, i-HPMC ingaphinde ichithekile kwezinye izixazululo ze-organic, ikakhulukazi lezo ezinezinga elithile lezimpawu ze-polar. Lokhu kufaka phakathi:
Ama-Alcohols: I-HPMC ikhombisa i-soubity enhle ngotshwala obuphansi njenge-methanol, ethanol ne-isopropanol. Ama-alcohol aphezulu awasebenzi kahle ngenxa yamaketanga abo amade we-hydrophobic.
Ama-Glycols: I-PlyLyene Glycol ne-Polythylene Glycol (PEG) ingancibilikisa i-HPMC. Lezi zinhlava zivame ukusetshenziswa ngokuhlanganiswa namanzi noma ama-alcohols ukuthuthukisa i-solubity kanye nokuqina kwesisombululo.
Ama-Ketones: Amakhethini athile afana ne-acetone no-methyl ethyl ketone angancibilikisa i-HPMC, ikakhulukazi uma ixutshwe namanzi.
3. Izingxube
I-HPMC nayo ingachithwa ngokuxutshwa kwe-solvent. Isibonelo, ukuhlanganisa amanzi notshwala noma ama-glycols angathuthukisa i-solubity. I-pernergy phakathi kwe-solvents inganciphisa ukugxila okudingekayo kwanoma iyiphi i-solvent eyodwa, ukulungiselela ukuqedwa.
Indlela yokuqothula
Ukuchithwa kwe-HPMC kuma-solvents kubandakanya ukwephula amabutho aphakathi phakathi kwamaketanga we-HPMC nokwakha ukusebenzisana okusha ngama-molecule e-solvent. Izici ezithonya le nqubo zifaka:
I-Hydrogen Bonding: I-HPMC yakha ama-hydrogen bond ngamanzi namanye ama-sol sol sol, okwenza i-solubity.
Ukusebenzisana kwe-polymer-solvent: Amandla we-solvent molecule ukungena nokuxhumana namaketanga we-HPMC athinta ukusebenza kahle.
Ukuqashwa Kwemishini: Okushukumisayo kusiza ekuphuleni ama-aggregates futhi kuthuthukisa ukuchithwa okufanayo.
Ukucatshangelwa okusebenzayo kokuqeda i-HPMC
1. Indlela yokuchithwa
Ngokuchithwa okusebenzayo, landela lezi zinyathelo:
Ukungezwa kancane kancane: Ngena kancane kancane i-HPMC kwi-solvent ngokuvuselelwa njalo ukuze uvikele ukuqina.
Ukulawulwa kokushisa: Dissolve HPMC emanzini abandayo ukugwema ukubheja ngaphambi kwesikhathi. Kwamanye ama-sollic arganic, ukufudumala okuncane kungasiza.
Amasu wokuxuba: Sebenzisa izitha zoMshini noma ama-homogenizer ngokuxubha okusebenzayo, ikakhulukazi ekugxileni okuphezulu.
2. Ukugxila nokubonakala
Ukuhlushwa kwe-HPMC kuthinta i-viscosity yekhambi:
Ukuhlushwa okuphansi: kuphumela kusisombululo esiphansi-esisheshayo, esilungele izinhlelo zokusebenza ezinjengezimbobo noma ama-linder.
Ukuhlushwa okuphezulu: Kwakha isixazululo esiphezulu noma i-gel, ewusizo ekuthini amakhethini emithi wokukhishwa okulawulwayo.
3. Ukuvumelana
Lapho usebenzisa i-HPMC ngokwakhiwa, qinisekisa ukuhambisana nezinye izithako:
Ukuqina kwe-PH: Qinisekisa ukuthi ezinye izakhi aziguquki i-PH edlula ibanga elizinzile le-HPMC.
Ukuzwela okushisa: Cabanga ngempahla eshisayo ye-gelation lapho uklama izinqubo ezibandakanya ushintsho lokushisa.
Izicelo zezixazululo ze-HPMC
Izisombululo ze-HPMC ziqashwa kuzo zonke izimboni ezahlukahlukene ngenxa yezakhiwo zazo ezihlukile:
1. Izemithi
I-HPMC isebenza njenge-binder, ifilimu yangaphambili, ne-ejenti yokukhishwa elawulwa:
Amathebulethi nama-capsule: Izixazululo ze-HPMC zisiza ekubopha izithako kanye nokwakha amafilimu ngokukhishwa kwezidakamizwa okulawulwayo.
Ama-gels: asetshenziswa ekwakhiweni okuphezulu kwezindawo zawo zokuqina nokuzinza.
2. Imboni yokudla
Njengesengezo sokudla, i-HPMC isetshenziselwa ukuqina kwayo nokuqinisa izakhiwo:
Ama-Fireners: Kuthuthukisa ukuthungwa nokuqina kusoso kanye nokugqoka.
Ukwakheka kwamafilimu: Kwakha amafilimu adliwayo for izimbobo kanye nama-emculiso.
3. Ukwakha
Izixazululo ze-HPMC zithuthukisa izakhiwo zezinto zokwakha:
Usimende noDinga: Kusetshenziswa njenge-ejenti yokugcinwa kwamanzi kanye namanzi emikhiqizweni esekwe kuthusi.
Amapende nezimbobo: kunikeza ukulawulwa kwe-Rheological nokuqina kupende.
Amasu wokuqothula athuthukile
1. I-Ultrasonication
Kusetshenziswa amagagasi e-ultrasonic ukuncibilikisa i-HPMC kungathuthukisa izinga lokuchithwa kanye nokusebenza kahle ngokwephula izinhlayiya nokukhuthaza ukuhlakazeka okufanayo.
2. Ukuxuba okuphezulu okuphezulu
Ama-Mixers aphezulu-shear ahlinzeka ngokuxuba okukhulu, anciphise isikhathi sokuqothula kanye nokwenza ngcono i-homogeneity, ikakhulukazi ekuvunyelweni okuphezulu.
Ukucatshangelwa Kwezemvelo Nezokuphepha
1. I-BiodegradeAbility
I-HPMC iyi-biodegradable, okwenza kube nobungani bemvelo. Kuhlekisa ngezinto zemvelo, kunciphisa umthelela wezemvelo.
2. Ukuphepha
I-HPMC ayinangozi futhi iphephile ukuze isetshenziswe ekudleni, emikhakheni kanye nezimonyo. Kodwa-ke, amashidi wedatha yokuphepha (SDS) kufanele abukezwe ukuze aphathe izinkombandlela zokugcina nokugcina.
Ukucibilikisa i-HPMC ngokuphumelelayo kudinga ukuqonda izici zayo ze-solubity kanye nokudlala okuxhumene nama-solvents ahlukile. Amanzi ahlala e-solvent eyinhloko, kanti utshwala, ama-glycols, kanye ne-solvent mixturetureturetureturetureturetures banikela ngezinye izixazululo zohlelo lokusebenza oluthile. Amasu afanele kanye nokucatshangelwa kuqinisekisa ukuqedwa okusebenzayo, ukulungiselela ukusetshenziswa kwezinto eziguquguqukayo ze-HPMC kuyo yonke imboni.
Isikhathi sePosi: Jun-14-2024