I-Hydroxypropyl methylcellulose (HPMC) yi-polymer ye-polymer engenasisekelo engeyona eye-polymer etholwe ukuguqulwa kwamakhemikhali kwe-cellulose yemvelo. Kusetshenziswa kabanzi ekudleni, umuthi, izimonyo kanye nezimboni zokwakha, ikakhulukazi njenge-adhesive, sikhulu, emulsifier kanye ne-ejenti esondelani emashashini amakhambi. Enqubweni yokufaka isicelo, izici ze-viscosity zekhambi le-HPMC elinamanzi zibalulekile ekusebenzeni kwalo emikhakheni ehlukene.
1. Ukwakheka kanye nezakhiwo ze-hydroxypropyllylylylyll methylcellulose
Ukwakheka kwamangqamuzana kwe-HPMC kuqukethe amaqembu amabili afanayo, i-hydroxypropyl (-ch₂Isiqukiso₃) ne-methyl (--OCH₃), okwenza kube nekhono elihle le-solubity kanye nekhono lokuguqulwa. I-HPMC Molecular chain inesakhiwo esithile esiqinile, kepha ingakha isakhiwo senethiwekhi enezici ezintathu esikhani esinamanzi, okuholela ekwandeni kokubonakala. Isisindo sayo samangqamuzana, uhlobo lokufakwa esikhundleni kanye ne-degree yokufaka esikhundleni (ie, izinga le-hydroxypropyl kanye ne-methyl subinitunce yeyunithi ngalinye) banethonya elibalulekile ekubonisweni kwesixazululo.
2. Izici ze-Viscosity zesisombululo esinamanzi
Izici ze-Viscosity zekhambi le-HPMC elinamanzi zihlobene kakhulu nezinto ezifana nokuhlushwa, isisindo samangqamuzana, izinga lokushisa kanye nenani le-pH le-solvent. Ngokuvamile, ukubukeka kwe-HPMC aquad solution kwanda ngokwanda kokuhlushwa kwayo. I-viscosity yayo ikhombisa ukungaziphathi kahle okungekho emthethweni kwe-bherlogical
(1) Umphumela Wokuhlushwa
Kunobudlelwano obuthile phakathi kokubonakala kwekhambi lamanzi le-HPMC kanye nokuhlushwa kwalo. Njengoba ukugcwala kwe-HPMC kukhuphuka, ukuhlangana kwamangqamuzana kusisombululo esinamanzi kuthuthukiswa, futhi ukufakwa kanye nokuxhumeka kwamaketanga ama-molelisar, okuholela ekukhuphukeni kwesixazululo. Ekugxilisweni okuphansi, i-viscosity ye-HPMC emanzi enomane ikhulisa ngokuqondile ngokwanda kokuhlushwa, kepha lapho kugxila kakhulu, ukukhula kwe-viscosity yekhambi kuvame ukuba yiflethi futhi kufinyelela inani elizinzile.
(2) Umphumela wesisindo se-molecular
Isisindo samangqamuzana se-HPMC sithinta ngqo ukubonwa kwesisombululo salo esinamanzi. I-HPMC enesisindo esiphakeme samangqamuzana inamaketanga amahle ama-molecular futhi angakha isakhiwo senethiwekhi enobukhulu obukhulu esikhandile esikhaleni esinamanzi, okuholela ekubonakaleni okuphezulu. Ngokuphambene nalokho, i-HPMC enesisindo esiphansi samangqamuzana inesakhiwo senethiwekhi ethambile kanye ne-viscosity ephansi ngenxa yamaketanga amhlophe afushane. Ngakho-ke, lapho ufaka isicelo, kubaluleke kakhulu ukukhetha i-HPMC ngesisindo esifanelekile sokuthola umphumela omuhle we-viscosity.
(3) Umphumela wokushisa
Ukushisa kuyinto ebalulekile ethinta ukubonakala kwesisombululo samanzi se-HPMC. Njengoba izinga lokushisa likhuphuka, ukunyakaza kwama-molecule amanzi kuyaqina futhi ukubonwa kwesixazululo kuvame ukwehla. Lokhu kungenxa yokuthi lapho izinga lokushisa likhuphuka, inkululeko yokwenyuka kwama-hpmc ama-molecular i-chain kanye nokuxhumana phakathi kwama-molecule kuya buthaka, ngaleyo ndlela kunciphise ukubonwa kwesixazululo. Kodwa-ke, impendulo ye-HPMC kusuka kuma-batch ahlukene noma imikhiqizo yokushisa ingahle ibuye ihluka, ngakho-ke izimo zokushisa zidinga ukulungiswa ngokuya ngezidingo ezithile zesicelo.
(4) Umphumela wenani le-PH
I-HPMC ngokwayo iyingxenye engeyona eye-ionic, futhi ukubonakala kwesisombululo sayo esinamanzi kuyazwela izinguquko ku-pH. Yize i-HPMC ibonisa izici zokuvota ezizinzile ezizinzile noma ezindaweni ezingathathi hlangothi, i-solubity kanye nokubona kwe-HPMC kuzothinteka ezindaweni ezine-acidic noma ze-alkali. Isibonelo, ngaphansi kwe-acid enamandla noma izimo ezinamandla ze-alkali, ama-molecule we-HPMC angahlanzwa ngokwengxenye, ngaleyo ndlela anciphise ukubonwa kwesisombululo sawo esinamanzi.
3. Ukuhlaziywa kwamehlo kwezimpawu ze-viscosity zekhambi le-HPMC elinamanzi
Ukuziphatha kwe-rheological kwesisombululo samanzi se-hpmc kuvame ukukhombisa izici ezingewona ama-fluid, okusho ukuthi ukubonakala kwalo akuhlobene nezici nje njengokuhlushwa kwesixazululo kanye nesisindo se-moleecular, kodwa futhi nokugunda kwesisindo. Ngokuvamile, emazingeni aphansi we-shear, ikhambi lamanzi le-HPMC libonisa ukubonakala okuphezulu, kuyilapho izinga le-shear liyanda, i-visa viscosity iyancipha. Lokhu kuziphatha kubizwa ngokuthi "ukuncipha kwe-shear" noma "ukuncipha kwe-shear" futhi kubaluleke kakhulu ezinhlelweni eziningi ezisebenzayo. Isibonelo, emasimini e-Coatings, amalungiselelo emithi, ukucubungula ukudla, njll.
4. Ezinye izinto ezithinta ukubonakala kwesisombululo samanzi se-HPMC
(1) Umphumela kasawoti
Ukungezwa kwamasawoti (njenge-sodium chloride) kungangezelela ukubonakala kwesisombululo esinamanzi se-HPMC. Lokhu kungenxa yokuthi usawoti angathuthukisa ukuxhumana phakathi kwama-molecule ngokushintsha amandla e-ionic wesixazululo, ukuze ama-molecule we-HPMC akha i-viscosity ethe xaxa. Kodwa-ke, umphumela wohlobo lukasawoti kanye nokuhlushwa okubonakalayo okubuye kudingeke kulungiswe ngokwezimo ezithile.
(2) Umphumela wezinye izengezo
Ukungeza ezinye izengezo (ezinjengezinto ezisetshenziswayo, ama-polymers, njll.) Ku-HPMC aquad Solution zizothinta nokuvunywa. Isibonelo, ama-surfactants anganciphisa ukubonwa kwe-HPMC, ikakhulukazi lapho okuhlushwa okungapheli kuphakeme. Ngaphezu kwalokho, ama-polymers athile noma izinhlayiya nazo zingasebenzisana ne-HPMC futhi zishintshe izakhiwo zesithando zalo.
Izici ze-Viscosity zehydroxypropyl methylcellulose Isixazululo esinamanzi siyathinteka ezicini eziningi, kufaka phakathi ukugxila, okushisa, izinga lokushisa, i-verc. Ukuqonda kanye nokwenza kahle lezi zici ze-viscosity kuzosiza ukwandisa ukusetshenziswa kwe-HPMC ezisetshenzisweni ezahlukahlukene. Kuzinhlelo zokusebenza ezisebenzayo, uhlobo lwe-HPMC olufanele kanye nemibandela yenqubo kufanele ikhethwe ngokuya ngezidingo ezithile zokuthola ukubonakala okuhle kanye ne-rheological Properties.
Isikhathi sePosi: Mar-01-2025