I-Hydroxypropyl Methylcellulose (HPMC) iyinhlangano ebalulekile ye-cellulose ether eye yasetshenziswa kabanzi ezinkambeni eziningi zezimboni ngenxa yezakhiwo zayo ezihlukile zenyama nangamakhemikhali. Izakhiwo zalo ze-viscosity zingenye yezindawo ezibaluleke kakhulu ze-HPMC, zithinta ngokuqondile ukusebenza kwayo ezinhlelweni ezahlukahlukene.
1. Izici eziyisisekelo ze-HPMC
I-HPMC iyi-ether ye-annoinic celvulosise etholwe ngokufaka ingxenye yamaqembu e-hydroxyl (-oh) ku-molecule ye-cellulose ngamaqembu we-methoxy (-Och3) kanye namaqembu we-hydroxypropyl (-Ach2ch (oh) CH3). Ine-soubity enhle emanzini kanye nezinye izixazululo ze-organic, yakha izixazululo zeColloidal. I-viscosity ye-HPMC inqunywa ikakhulukazi ngesisindo sayo samangqamuzana, izinga lokufaka esikhundleni (DS, degree lokufaka esikhundleni) kanye nokusatshalaliswa okuphezulu.
2. Ukunqunywa kokubonakala kwe-HPMC
I-viscosity yezixazululo ze-HPMC ivame ukukalwa kusetshenziswa i-vezcometer ejikelezayo noma i-visecometer ye-capillary. Lapho ukukala, ukunakwa kudinga ukukhokhelwa ekuhluthelweni, izinga lokushisa kanye nesixazululo sekhambi, njengoba lezi zinto zingathinta kakhulu inani le-viscosity.
Ukuhlushwa kwesixazululo: I-viscosity ye-HPMC inyuka ngokwanda kwesixazululo. Lapho ukugcwala kwesixazululo se-HPMC kuphansi, ukuxhumana phakathi kwama-molecule kubuthakathaka futhi ukuhlakanipha kuphansi. Njengoba ukuhlushwa kukhula, ukufakwa kanye nokuxhumana phakathi kwama-molekyuli kuyanda, kubangele ukwanda okukhulu kokubonakala.
Ukushisa: I-viscosity yezixazululo ze-HPMC zizwela kakhulu izinga lokushisa. Ngokuvamile, njengoba izinga lokushisa likhuphuka, ukubonakala kwesisombululo se-HPMC kuzokwehla. Lokhu kungenxa yokwanda kwezinga lokushisa okuholela ekunyuseni ukunyakaza kwamangqamuzana kanye nokusebenzisana okubuthakathaka kwe-intermolecular. Kumele kwaziwe ukuthi i-HPMC enamazinga ahlukene wokufaka esikhundleni kanye nesisindo se-molecular inokuzwela okuhlukile kokushisa.
Izinga le-Shear: Izixazululo ze-HPMC zibonisa indlela yokuziphatha ye-Pseudoplastic (ie i-viscosity iphakeme ngamanani aphansi we-shear futhi anciphe amazinga aphezulu we-shear. Lokhu kuziphatha kungenxa yamandla we-shear avumelanisa amaketanga ama-molecular eceleni kwe-shear ukuqondiswa, ngaleyo ndlela anciphise ukufakwa kanye nokusebenzisana phakathi kwama-molecule.
3. Izici ezithinta i-HPMC Viscosity
Isisindo samangqamuzana: Isisindo samangqamuzana se-HPMC singesinye sezinto ezibalulekile ezinquma ukubonana kwayo. Ngokuvamile, ubukhulu besisindo se-molecular, ukukhuphuka kwesixazululo. Lokhu kungenxa yokuthi ama-molecule we-HPMC anesisindo esiphakeme samangqamuzana maningi amathuba okuthi ahlole amanethiwekhi afakiwe, ngaleyo ndlela akhuphuke ukungqubuzana kwangaphakathi kwesixazululo.
I-degree yokufakwa esikhundleni kanye nokusatshalaliswa okuphezulu: Inombolo nokusabalalisa kwe-Methoxy kanye ne-hydroxypropylst ku-HPMC kuthinta nakho okubonakalayo kwayo. Ngokuvamile, kukhuphuka isikhundla sokufakwa esikhundleni se-methoxy (DS), ukwehlisa ukubonakala kwe-HPMC, ngoba ukwethulwa kokufaka esikhundleni se-metholy kuzonciphisa amandla okubopha ama-hydrogen phakathi kwama-molecule. Ukungeniswa kweHydroxypropp supply kuzokhulisa ukusebenzisana kwe-intermolecular, ngaleyo ndlela kwandise ukubonakala. Ngaphezu kwalokho, ukusatshalaliswa komfaniswano wokufaka esikhundleni kwalabo abasiza ukwakha uhlelo oluzinzile lokukhangela futhi kwandise ukubonakala kwesisombululo.
Ivelu yekhambi lekhambi: Yize i-HPMC i-polymer engeyona eye-ionic futhi i-viscosity yayo ayinandaba nezinguquko evezweni ye-PH yekhambi lesisombululo, amanani we-PH aphezulu (kakhulu noma i-alkaline) angadala ukonakaliswa kwesakhiwo samangqamuzana I-HPMC, ngaleyo ndlela ithinta ukubonakala.
4. Izinkambu zohlelo lokusebenza lwe-HPMC
Ngenxa yezici zayo ezinhle kakhulu ze-viscosity, i-HPMC isetshenziswa kabanzi emikhakheni eminingi:
Izinto zokwakha: Ezintweni zokwakha, i-HPMC isetshenziswa njenge-Swerener ne-ejenti yokugcina amanzi ukuze kuthuthukiswe ukusebenza kokwakha futhi kwandise ukumelana nokuqhekeka.
Imboni yezemithi: Embonini yezemithi, i-HPMC isetshenziswa njenge-binder yamathebulethi, umenzeli owakha amafilimu amakhompiyutha kanye nesiphathi sezidakamizwa ezikhethekile.
Imboni yokudla: I-HPMC isetshenziswa njengesikhudlwana kanye ne-stabilizer embonini yokudla ukuze kukhiqizwe u-ayisikhilimu, ukukhiqizwa kwe-jelly nemikhiqizo yobisi.
Imikhiqizo yamakhemikhali yansuku zonke: emikhiqizweni yansuku zonke yamakhemikhali, i-HPMC isetshenziswa njengesikhudlwana kanye ne-stabilizer for ukukhiqizwa kwe-shampoo, i-gel yokugeza, amazinyo, njll.
Izici ze-Viscosity ze-HPMC ziyisisekelo sokusebenza kwayo okuhle ezisetshenzisweni ezahlukahlukene. Ngokulawula isisindo samangqamuzana, izinga lokufaka esikhundleni, nezimo zesisombululo se-HPMC, i-viscosity yayo ingashintshwa ukuze ihlangabezane nezidingo ezihlukile zohlelo lokusebenza. Esikhathini esizayo, ucwaningo olunzulu ngobudlelwano phakathi kwesakhiwo samangqamuzana e-HPMC kanye ne-viscosity kuzosiza ukuthuthukisa imikhiqizo ye-HPMC ngokusebenza okungcono futhi kuphinde kwandise izinkambu zayo zohlelo lokusebenza.
Isikhathi sePosi: Jul-20-2024