Ukugcinwa kwamanzi kuyindawo ebalulekile yezimboni eziningi ezisebenzisa izinto ze-hydrophilic ezinjenge-cellulose afes. I-Hydroxypropylmethylcellellellellellulose (HPMC) ingenye yezitha ze-cellulose enezinto eziphakeme zokugcina amanzi. I-HPMC iyi-polymer ye-semi-zokwenziwa ethathwe ku-cellulose futhi ivame ukusetshenziswa ezinhlobonhlobo zezicelo ekwakhiweni, ezenza imithi kanye nezimboni zokudla.
I-HPMC isetshenziswa kabanzi njengomuntu omkhulu, i-stabilizer kanye ne-emulsifier emikhiqizweni yokudla ehlukahlukene efana ne-ayisikhilimu, amasoso kanye nokugqoka ukuthuthukisa ukuthungwa kwazo, ukungaguquguquki kanye nempilo eshalofini. I-HPMC nayo isetshenziswa ekukhiqizweni kwemithi embonini yezemithi njenge-binder, ukuqhelelana ne-ejenti ye-film coating. Iphinde isetshenziswe njenge-ejenti yokugcina amanzi ezintweni zokwakha, ikakhulukazi kuso usimende nodaka.
Ukugcinwa kwamanzi kuyindawo ebalulekile ekwakheni ngoba kusiza ukugcina usimende osanda kuxutshwa nodaka ekumisweni komiswa. Ukomisa kungadala ukushwabana nokuqhekeka, okuholela kwizakhiwo ezibuthakathaka nezingazinzile. I-HPMC isiza ukugcina okuqukethwe kwamanzi ku-usimende nodaka ngokuthola ama-molekyuli amanzi futhi kukhulule kancane ngokuhamba kwesikhathi, kuvumela izinto zokwakha ukuze zokwelapha kahle futhi zilukhuni.
Umgomo wokugcina amanzi we-HPMC ususelwa ku-hydrophility yayo. Ngenxa yokuba khona kwamaqembu e-hydroxyl (-OH) esakhiweni sayo samangqamuzana, i-HPMC inokuhlangana okuphezulu kwamanzi. Amaqembu e-Hydroxyl axhumana nama-molecule wamanzi ukwakha ama-hydrogen bond, okuholela ekwakhekeni kwe-hydration shell ezungeze amaketanga we-polymer. I-Shell e-hydrate ivumela amaketanga we-polymer ukukhulisa, andise ivolumu ye-HPMC.
Ukuvuvukala kwe-HPMC kuyinqubo enamandla okuncike ezintweni ezahlukahlukene ezifana nezinga lokufaka esikhundleni (DS), usayizi wezinhlayiyana, izinga lokushisa kanye ne-ph. Izinga lokufaka esikhundleni lisho inani lamaqembu afakwa esikhundleni se-hydroxlucose uphiko ngeyunithi ye-anhydroglucose ku-cellulose chain. Inani eliphakeme le-DS, likhuphuka i-hydrophicity kanye nokusebenza okungcono kokusebenza kwamanzi. Ubukhulu bezinhlayiyana be-HPMC buthinta nokugcinwa kwamanzi, njengoba izinhlayiya ezincane zinendawo enkulu engaphezulu yeyunithi ngayinye, okuholela ekuthobeni kwamanzi okukhulu. Ukushisa nenani le-PH kuthinta izinga lokuvuvukala nokugcinwa kwamanzi, kanye nokushisa okuphezulu kanye nenani eliphansi le-PH ukuthuthukisa izici zokugcina amanzi ze-HPMC.
Indlela yokugcina amanzi ye-HPMC ifaka izinqubo ezimbili: ukumuncwa kanye nokukhuphuka. Ngesikhathi kutholwa, i-HPMC idonsa ama-molecule wamanzi asendaweni ezungezile, yakha igobolondo le-hydration elizungeze amaketanga we-polymer. I-Hydration Shell ivimbela amaketanga we-polymer kusuka ekuweni futhi uwagcina ahlukaniswe, okuholela ekuvuvukeni kwe-HPMC. Ama-molecule wamanzi amunwe athola amafomu ama-hydrogen ngamaqembu ama-hpdroxy ku-HPMC, athuthukise ukusebenza kokugcinwa kwamanzi.
Ngesikhathi sokuhunyushelwa, i-HPMC ikhipha kancane ama-molecule wamanzi, avumele izinto zokwakha zokwelapha kahle. Ukukhishwa okuhamba kancane kwama-molecule amanzi kuqinisekisa ukuthi usimende nodaka kuhlala kugcwele amanzi ngokuphelele, okuholela ekwakhekeni okuqinile futhi okuhlala isikhathi eside. Ukukhishwa okuhamba kancane kwama-molecule wamanzi nakho kuhlinzeka ngokuhlinzekwa kwamanzi ku-ceyili nodaka, ukuthuthukisa inqubo yokulapha futhi kwandise amandla nokuqina komkhiqizo wokugcina.
Ngamafuphi, ukugcinwa kwamanzi kuyindawo ebalulekile yezimboni eziningi ezisebenzisa izinto ze-hydrophilic ezinjenge-cellulose afes. I-HPMC ingenye yezitha ze-cellulose afers enezindawo eziphakeme zokugcina amanzi futhi isetshenziswa kabanzi ekwakheni, izimboni zemithi kanye nokudla. Izakhiwo zokugcinwa kwamanzi ze-HPMC zisuselwa ku-hydrophicility yayo, okuvumela ukuthi zithole ama-molecule wamanzi asuka endaweni ezungezile, akha i-hydration shell ezungeze amaketanga we-polymer. I-Shell e-hydrate ibangela ukuthi i-HPMC ikhule, futhi ukukhululwa kancane kwama-molecule amanzi kuqinisekisa ukuthi izinto zokwakha zihlala zinamanzi agcwele, okuholela ekwakhekeni okuzinzile futhi okudala.
Isikhathi sePosi: Aug-24-2023