I-Hypromellose, eyaziwa nangokuthi i-hydroxypropyllym methylcellulose (HPMC), iyinhlangano eguquguqukayo ye-semi-sonthetic polymer ethathwe ku-cellulose. Ngenxa yezakhiwo zayo ezihlukile zamakhemikhali nezomzimba, i-HPMC isetshenziswa kakhulu njengomuntu omkhulu, i-stabilizer kanye nokunamathela emikhakheni yokunakekelwa kwemithi, yokudla kanye nezimboni. Kulesi sihloko, sixoxa ngamakhemikhali ama-HPMCS nezinhlelo zawo ezibalulekile.
1. I-Solubity
Enye yezakhiwo zamakhemikhali ezibaluleke kakhulu ze-HPMC yi-solubility yayo. I-HPMC iyanyibilika emanzini futhi i-organic solvents amaningi, okwenza kube yingxenye efanelekile yezinhlelo zokulethwa kwezidakamizwa nezinye izinhlelo zidinga ukuqedwa. Kodwa-ke, i-solubility ye-HPMC inqunywe kakhulu ngezinga layo lokufaka esikhundleni (DS), elinquma inani le-hydroxypropyll kanye namaqembu we-methyl akhona ku-polymer chain. Ama-HPMC anama-DS aphezulu ane-solubity ephansi ngenxa yokusebenzisana okwengeziwe kwe-intermolecular.
2. Rheology
Enye into ebalulekile yamakhemikhali ye-HPMC yokuziphatha kwayo okungokomfanekiso. Amandla we-HPMC ukwakha inethiwekhi ye-gel-efana ne-hydration angasetshenziselwa ukulawula i-viscosity kanye nokugeleza kwezimpawu zokwakheka. I-HPMC ibuye ibuye ikhombise isenzo sokugeleza esingelona neNewnTonian, okusho ukuthi i-viscosity yayo ishintsha ngokuya ngesilinganiso se-shear esisetshenzisiwe. Le mpahla ingaphinde ilawulwe futhi ngokulungisa ukugcwala kwe-HPMC kanye ne-DS ekwakhekeni.
3. Ukwakheka kwefilimu
I-HPMC nayo isetshenziswa kabanzi njengefilimu yangaphambili ngenxa yekhono layo lokwakha amafilimu afanayo lapho isetshenziswa ku-substrate. Izakhiwo ezenziwe ngefilimu ze-HPMC zincike kuma-DS aso, ukubonakala kanye nokuba khona kopulasitiki, okungathuthukisa ukuqina nokuguquguquka kwefilimu. Amafilimu enziwe nge-HPMC asetshenziswa kakhulu ekulethweni kwezidakamizwa ngoba avumela ukukhishwa okulawulwayo kwezithako ezisebenzayo.
4. Ukuvumelana
I-HPMC iyi-excipient ehambelana kakhulu futhi ingasetshenziswa ekwakhekeni okuhlukahlukene. Iyahambisana nezithako zemithi eziningi kakhulu, kufaka phakathi izithako ezisebenzayo zemithi (ama-API) namanye ama-excipie asetshenziswa kakhulu ekwakhiweni kwemithi. I-HPMC nayo iyahambisana nezithako eziningi zokudla, okwenza kube ukukhetha okuthandwa kwezicelo zokudla.
5. Ukuqina kwamakhemikhali
I-HPMC iyi-polymer ezinzile ephikisana ne-hydrolysis kanye nokunye ukusabela kwamakhemikhali. Lokhu kuzinza kwenza kube yisithako esifanele ezinhlelweni zokulethwa kwezidakamizwa njengoba zivikela isithako esisebenzayo ekujuleni nasekukhuliseni ama-bioavailability alo. Kodwa-ke, ukuqina kwamakhemikhali i-HPMC kungathinteka ekushiseni okuphezulu, umswakama ophezulu, kanye nobunye obuthile, obungadala ukuthi i-polymer ibe yinciphile futhi inciphise ukusebenza kwayo ngokwakhiwa.
6. Ukuqina
Ekugcineni, i-HPMC iyi-polymer ehambisanayo ephephile ukuze isetshenziswe kuma-Pharmaceuticals kanye nemikhiqizo yokunakekelwa komuntu siqu. Akuyona into enobuthi, ingekho-imunogenic ne-biodebradable, okwenza kube yinto elungele ukwakheka okudinga ubuthi obuncane kanye nokuphepha okukhulu.
Ngokufingqwa, i-HPMC Hypromellose iyi-polymer ephathekayo enobubanzi bezindawo zamakhemikhali ezibalulekile, kufaka phakathi i-solubity, i-Rhelogy, izakhiwo ezakha amafilimu, ukuhambisana, ukuqina kwamakhemikhali, kanye nokuqina kwamakhemikhali. Lezi zakhiwo zikwenza kube yinto enhle enhle yezinhlelo zokulethwa kwezidakamizwa kanye nezinye izinhlelo zokusebenza ekudleni nasezimbonini zokunakekelwa komuntu siqu. Njengoba ucwaningo luqhubeka nokwandisa ukuqonda kwethu ngama-HPMC, izakhiwo zazo ezihlukile zingathola izinhlelo ezibanzi ngokuzayo.
Isikhathi sePosi: Jul-28-2023