I-Hydroxypropylm methylcellulose (HPMC) iyisengezo esibalulekile samakhemikhali, esetshenziswa kabanzi emikhakheni eminingi efana nokwakha, umuthi, ukudla nezimonyo. Inokuqina okuhle, ukucekelwa phansi, i-eculsise, kwakha amafilimu, kanye nezakhiwo ezibophayo, futhi inokuqina okuthile ekushiseni nase-pH. I-solubity ye-HPMC ingenye yezinkinga ezibalulekile ekusebenziseni kwayo. Ukuqonda indlela efanele yokuqothula kubalulekile ukuze uqinisekise ukusebenza kwawo.
1. Izakhiwo eziyisisekelo zokuchithwa kwe-HPMC
I-Hydroxypropyl Methylcellulose iyi-ether engenawo amanzi angenayo amanzi angachithwa kumanzi abandayo noma ashisayo ukwakha isixazululo esibonakalayo noma esibonakalayo. I-solubility yayo ithinteka kakhulu izinga lokushisa. Kulula ukuncibilikisa emanzini abandayo futhi kulula ukwakha i-colloid emanzini ashisayo. I-HPMC ine-gelation eshisayo, okungukuthi, ine-solubility empofu emazingeni okushisa aphezulu, kepha ingachithwa ngokuphelele lapho izinga lokushisa lehliswa. I-HPMC inezinsimbi ze-molecular ezahlukahlukene kanye nama-viscosities, ngakho-ke ngesikhathi sokuchithwa, imodeli efanele ye-HPMC kufanele ikhethwe ngokuya ngezidingo zomkhiqizo.
2. Indlela yokuchithwa kwe-HPMC
Indlela yokuhlakazwa kwamanzi ebandayo
Indlela yokuhlakazeka kwamanzi ebandayo iyindlela esetshenziswa kakhulu ye-HPMC yokuqothula futhi ilungele izimo eziningi zohlelo lokusebenza. Izinyathelo ezithile zinjengokulandelayo:
Lungiselela amanzi abandayo: uthele inani elidingekayo lamanzi abandayo esitsheni sokuxuba. Izinga lokushisa lamanzi livame ukunconyelwa ukuba ngaphansi kwama-40 ° C ukugwema i-HPMC kusuka ekwakheni izigaxa emazingeni okushisa aphezulu.
Kancane kancane engeza i-HPMC: Ngena kancane kancane i-HPMC powder bese uqhubeka nokuvusa. Ukuze ugweme i-agglomeration ye-powder, kufanele kusetshenziswe isivinini esifanelekile sokuvuselela ukuqinisekisa ukuthi i-HPMC ingahlakazeka ngokulinganayo emanzini.
Ukuma nokuqedwa: Ngemuva kokuthi i-HPMC ihlakazeka emanzini abandayo, idinga ukuma isikhathi esithile sokuncibilika ngokuphelele. Imvamisa, kusele ukumi imizuzu engama-30 kuye emahoreni ambalwa, futhi isikhathi esithile siyehluka ngokuya ngemodeli ye-HPMC namazinga okushisa kwamanzi. Ngesikhathi senqubo yokuma, i-HPMC izoncibilika kancane ukwakha isixazululo se-viscous.
Indlela Eshisayo Yamanzi Ukuchithwa Kwendlela
Indlela eshisayo yokuchithwa kwamanzi ilungele amanye amamodeli we-HPMC anokubonakala okuphezulu noma okunzima ukuncibilikisa ngokuphelele emanzini abandayo. Le ndlela ukuqala ukuxuba i-powder ye-HPMC ngengxenye yamanzi ashisayo ukwakha unamathisela, bese uyixuba ngamanzi abandayo ekugcineni ekugcineni uthole isixazululo esifanayo. Izinyathelo ezithile zinjengokulandelayo:
Ukushisa Amanzi: Shisisa inani elithile lamanzi acishe abe ngu-80 ° C bese uwathela esitsheni sokuxuba.
Ukungeza i-HPMC powder: Thela i-powder ye-HPMC emanzini ashisayo bese uvusa ngenkathi uthela ukwakha ingxube yokunamathisela. Emanzini ashisayo, i-HPMC izoncibilikisa okwesikhashana futhi yakha into efana nejeli.
Ukungeza Amanzi Okubandayo ukuze ugcwalise: Ngemuva kwengxube yokunamathisela kuphole, kancane kancane engeza amanzi abandayo ukuze ulichithe bese uqhubeka uvuselelwa kuze kube yisixazululo esibonakalayo noma esibonakalayo.
Indlela ye-Organic Solvent Dispassion Discurity
Kwesinye isikhathi, ukuze asheshise ukuchithwa kwe-HPMC noma athuthukise umphumela wokuchithwa kwezinhlelo ezithile ezikhethekile, i-organic solvent ingasetshenziswa ukuxuba namanzi ukuncibilikisa i-HPMC. Isibonelo, izixazululo ze-organic ezifana ne-ethanol ne-acetone zingasetshenziswa ukusabalalisa i-HPMC kuqala, bese kuba namanzi kungangezwa ukusiza i-HPMC ichithe ngokushesha okukhulu. Le ndlela ivame ukusetshenziselwa ukukhiqizwa kwemikhiqizo ethile esekwe e-solvent, efana nezingubo kanye nopende.
Indlela Yokuxuba Esomile
Indlela esomile yokuxuba ilungele ukukhiqizwa kwezimboni ezinkulu zezimboni. I-HPMC imvamisa eyomile exutshwe nezinye izinto eziyimpuphu (njengokwenza usimende, i-gypsum, njll.), Bese kufakwa amanzi ukuxubana. Le ndlela yenza lula izinyathelo zokusebenza futhi igweme inkinga ye-aggglomeration lapho i-HPMC ichithwa yedwa, kepha idinga ukushukumisa okwanele ngemuva kokufaka amanzi ukuze kuqinisekiswe ukuthi i-HPMC ingachithwa ngokulinganayo futhi idlalwe indima enkulu.
3. Izici ezithinta ukuchithwa kwe-HPMC
Ukushisa: I-solubity ye-HPMC izwakala kakhulu ekushiseni. Izinga lokushisa eliphansi lilungele ukuhlakazeka kwalo nokuchithwa emanzini, ngenkathi izinga lokushisa eliphakeme libangela kalula i-HPMC ukuthi ifake ama-colloids, ukuvimbela ukuqondisisa kwayo okuphelele. Ngakho-ke, kuvame ukunconyelwa ukusebenzisa amanzi abandayo noma alawule izinga lokushisa lamanzi ngaphansi kwama-40 ° C lapho kuncibilika i-HPMC.
Isivinini esishukumisayo: Ukuvuselela okufanele kungakugwema ngempumelelo i-HPMC AGGGGOMELION, ngaleyo ndlela kusheshise izinga lokuchitheka. Kodwa-ke, ijubane elisheshayo kakhulu elishukumisayo lingaletha inani elikhulu lama-bubble futhi lithinte ukufana kwesixazululo. Ngakho-ke, ekusebenzeni kwangempela, ijubane elifanelekile lemishini kanye nemishini kufanele ikhethwe.
Ikhwalithi Yamanzi: Ukungcola, Ubulukhuni, Ivelu ye-PH, njll. Amanzi kuzothinta i-solubity ye-HPMC. Ikakhulu, i-calcium ne-magnesium e-ion emanzini anzima kungasabela nge-HPMC futhi kuthinte i-solubity yayo. Ngakho-ke, ukusebenzisa amanzi ahlanzekile noma amanzi athambile kusiza ukuthuthukisa ukusebenza kahle kwe-HPMC.
Imodeli ye-HPMC kanye nesisindo se-molecular: amamodeli ahlukene we-HPMC ahluka ngejubane lokuqothula, ukubonwa kanye nokushisa okuchithwayo. I-HPMC enesisindo esiphakeme samangqamuzana ayinciphise kancane, inesixazululo esiphezulu sokulungiselela, futhi ithatha isikhathi eside ukuncibilikisa ngokuphelele. Ukukhetha imodeli ye-HPMC efanele kungathuthukisa ukusebenza kahle futhi kuhlangatshezwane nezidingo zohlelo lokusebenza ezihlukile.
4. Izinkinga ezijwayelekile nezixazululo ekuchithekeni kwe-HPMC
Inkinga ye-Agglomeration: Lapho i-HPMC ichithwa emanzini, ama-agglomerations angakha uma i-powder ingahlakazwa ngokulinganayo. Ukugwema le nkinga, i-HPMC kufanele ingezwe kancane kancane ngesikhathi sokuchithwa futhi igcinwe ngejubane elifanelekile, ngenkathi ligwema ukwengeza i-HPMC powder emazingeni okushisa aphezulu.
Isixazululo Esingalingani Ngalesi sikhathi, isikhathi esivuthayo kufanele sinwetshwe noma isikhathi sokuma kufanele sikhuphuke ukuze siqinisekise ukuqondisisa okuphelele.
Inkinga ye-Bubble: Ukuvuselelwa okusheshayo kakhulu noma ukungcola emanzini kungangenisa inani elikhulu lama-bubble, okuthinta ikhwalithi yesisombululo. Ngalesi sizathu, kunconywa ukulawula ijubane lokuvuselela lapho kuchithwa i-HPMC ukugwema ama-bubble ngokweqile, bese wengeza i-desoamer uma kunesidingo.
Ukuchithwa kwe-HPMC kuyisixhumanisi esibalulekile ekusetshenzisweni kwayo. Ukwenza kahle indlela efanele yokuqothula isiza ukuthuthukisa ikhwalithi yomkhiqizo nokusebenza kahle kokukhiqiza. Ngokwezinhlobo ezahlukene zezidingo ze-HPMC nezicelo, ukuhlakazeka kwamanzi okubandayo, amanzi ashisayo okuchithwa, ukuhlakazwa kwe-organic solvent noma ukuxutshwa komile. Ngasikhathi sinye, ukunakwa kufanele kukhokhwe ukulawula izinto ezifana nezinga lokushisa, ijubane elishukumisayo nekhwalithi yamanzi ngesikhathi senqubo yokuqothula ukugwema izinkinga ezinjenge-agglomerali, ama-bubble kanye nokuchithwa okungaphelele. Ngokwenza kahle izimo zokuqothula, zingaqinisekiswa ukuthi i-HPMC ingapholisa ukudla okugcwele kwizakhiwo zayo zokuqina kanye nefilimu, ihlinzeka ngezixazululo ezisezingeni eliphakeme zohlelo lokusebenza oluhlukahlukene lwezimboni nansuku zonke.
Isikhathi sePosi: Sep-30-2024