I-Hydroxypropyl methylcellulose (HPMC)Ingabe i-ether engeyona eye-cellulose esetshenziswa kabanzi ezintweni zokwakha, umuthi, ukudla, izimonyo kanye nezinye izinkambu zezimboni. Inezakhiwo eziningi ezinhle kakhulu zomzimba, okwenza ukuthi zenze kahle ezinhlelweni ezahlukahlukene.
1. Ukubukeka kanye ne-solubility
I-HPMC imvamisa i-powder emhlophe noma ye-off-emhlophe, engenamzimba, engenamthambe futhi ingeyona into enobuthi. Ingachithwa emanzini abandayo kanye nama-sol athile we-organic (anjenge-solvents ahlanganisiwe njenge-ethanol / wamanzi ne-acetone / amanzi), kepha akwehlise i-ethanol emsulwa, ether kanye ne-chloroform. Ngenxa yemvelo yayo engeyona eye-ionic, ngeke ibhekane ne-electrolytic reatection kwisixazululo samanzi futhi ngeke ithinteke kakhulu ngenani le-PH.
2. I-Viscosity kanye Rheology
Isixazululo se-HPMC samanzi sinokuqina okuhle ne-thixotropy. Izinhlobo ezahlukene zeCedCencher®HPMC zine-viscosities ehlukile, futhi uhla olujwayelekile lungu-5 kuye ku-100000 MPA (2% COLULUSE, 20 ° C). Isixazululo saso sibonisa ubuhlakani, okungukuthi, shuar ukuncipha punomenon, futhi kufanelekile ukuthola izimo zohlelo lokusebenza njengezimbobo, ama-slurries, anamathela, njll.
I-3. I-gelation eshisayo
Lapho i-HPMC ifudunyezwa emanzini, ukucaca kwesixazululo kuyancipha futhi i-gel yakhiwa emazingeni okushisa athile. Ngemuva kokupholisa, isimo se-gel sizobuyela esimweni sokuxazulula isixazululo. Izinhlobo ezahlukahlukene ze-HPMC zinamazinga okushisa ahlukene we-gel, ngokuvamile phakathi kuka-50 no-75 ° C. Le mpahla ibaluleke kakhulu kuzinhlelo zokusebenza ezifana nodaka lwamapulangwe kanye nama-caplule emithi.
4. Umsebenzi ongaphezulu
Ngenxa yokuthi ama-molecule we-HPMC aqukethe amaqembu e-hydrophilic kanye ne-hydrophobic, akhombisa umsebenzi othile ongaphezulu futhi angadlala indima ethokozisayo, ehlakazayo kanye nokuzinza. Isibonelo, kuzimbali kanye nama-emulsion, i-HPMC ingathuthukisa ukuqina kwe-emulsion futhi ivikele ukuqunjelwa kwezinhlayiya ze-pigment.
5. I-Hygroscopicity
I-HPMC inokuhlanganiswa okuthile futhi ingadonsa umswakama endaweni enomswakama. Ngakho-ke, kwezinye izinhlelo zokusebenza, ukunakwa kufanele kukhokhwe ukupakisha ukubekwa uphawu ukuvikela ukumuncwa komswakama kanye ne-agglomeration.
6 Impahla ekwakheka ifilimu
I-HPMC ingakha ifilimu enzima futhi esobala, esetshenziswa kabanzi ekudleni, umuthi (njengama-ejenti we-coating) kanye nendwangu. Isibonelo, embonini yezemithi, ifilimu ye-HPMC ingasetshenziswa njenge-tablet coating ukuthuthukisa ukuqina kwezidakamizwa nokukhishwa kokulawula.
7. Ukuqina nokuphepha
I-HPMC ayinobuthi futhi ayinabungozi, futhi ingahlanganiswa ngokuphepha umzimba womuntu, ngakho-ke isetshenziswa kabanzi emikhakheni yezokwelapha nokudla. Njenge-Excipieint yezemithi, imvamisa isetshenziselwa ukukhiqiza amaphilisi wokukhishwa okuqhubekayo, amagobolondo e-capsule, njll.
8. Ukuqina kwe-PH kwesixazululo
I-HPMC iqinile ku-Ph Range Grange ye-3 kuye ku-11, futhi ayilonakaliswa kalula noma ifakwe nge-acid ne-alkali, ngakho-ke ingasetshenziswa ezinhlelweni ezahlukahlukene zamakhemikhali, njengezinto zokwakha, imikhiqizo yamakhemikhali yansuku zonke.
9. Ukumelana nosawoti
Isixazululo se-HPMC sizinzile ngokujwayelekile kusawoti we-inorganic futhi asikwazi ukunqotshwa kalula noma asisebenzi ngenxa yezinguquko e-Ion okuhlushwa, okuvumela ukuthi kugcinwe ukusebenza okuhle kwamasistimu aqukethe usawoti (njengosimende ngodaka).
10. Ukuqina okushisayo
ICECCENCELX®HPMC inokuqina okuhle ezindaweni eziphakeme zokushisa, kepha kungahlehlisa noma kuhlukanise uma kuvezwa amazinga okushisa aphezulu isikhathi eside. Kusakwazi ukugcina ukusebenza okuhle ngaphakathi kwebanga elithile lokushisa (imvamisa ngaphansi kwama-200 ° C), ngakho-ke kufanelekile ukuthola izinhlelo zokusebenza zokushisa okushisa.
11. Ukuqina kwamakhemikhali
I-HPMCKuyazinza kakhulu ukuKhanya, ama-oxidants namakhemikhali ajwayelekile, futhi akunakuthintwa kalula yizinto zamakhemikhali zangaphandle. Ngakho-ke, ingasetshenziswa emikhiqizweni edinga ukugcinwa isikhathi eside, njengezinto zokwakha nemithi.
I-Hydroxypropylylylyly isetshenziswa kabanzi kwizimboni eziningi ngenxa ye-solubility yayo enhle kakhulu, ukuqina, ukubekelwa phansi okushisayo, izakhiwo ezakha amakhemikhali kanye nokuqina kwamafilimu kanye nokuqina kwamakhemikhali kanye nokuqina kwamakhemikhali kanye nokuqina kwamakhemikhali. Embonini yezokwakha, ingasetshenziswa njengesikhisi sodaka esikhulu; Embonini yezemithi, ingasetshenziswa njenge-excipietical yekhamikhali; Embonini yokudla, kuyinto evamile yokudla. Yilezi zakhiwo ezihlukile ezibonakalayo ezenza i-HPMC ibe yizinto ezibalulekile ze-polymer.
Isikhathi sePosi: Feb-10-2025