Yiziphi izakhiwo ze-rheological ze-HPMC?

Yiziphi izakhiwo ze-rheologicalI-HPMC?

IHydroxypropyl methylcellulose (HPMC) iyi-polymer eguquguqukayo ethola ukusetshenziswa okubanzi ezimbonini ezahlukahlukene, kufaka phakathi ezemithi, ezokwakha, ukudla, nezimonyo, ngokuyinhloko ngenxa yezakhiwo zayo ezihlukile ze-rheological. I-Rheology iwucwaningo lokugeleza nokuguqulwa kwezinto, futhi ukuqonda izakhiwo ze-rheological ze-HPMC kubalulekile ekuthuthukiseni ukusebenza kwayo ezinhlelweni ezahlukene.

I-Viscosity: I-HPMC ibonisa i-pseudoplastic noma i-shear-thinning, okusho ukuthi i-viscosity yayo iyancipha ngokukhuphuka kwesilinganiso sokugunda. Lesi sakhiwo sibalulekile ekusetshenzisweni okufana nokwakhiwa kwemithi, lapho kuvumela ukupompa okulula, ukusabalalisa, nokusebenzisa. I-Viscosity ingalungiswa ngokulungisa izinga lokushintshwa (DS) nesisindo samangqamuzana e-HPMC.

Thixotropy: Thixotropy ibhekisela ekuguqukeni kwejeli-sol ehlehliswayo eboniswa izinto ezithile ngaphansi kwengcindezi yokugunda. Amajeli e-HPMC akhiwe ekuphumuleni angadilika ngaphansi kwe-shear futhi aphinde athole isakhiwo sawo sejeli lapho ukucindezeleka kususwa. Lesi sakhiwo sinenzuzo ezinhlelweni ezifana nopende, lapho kuvimbela ukuwohloka ngesikhathi sokufaka isicelo kodwa siqinisekisa ukumbozwa okufanele uma sekusetshenzisiwe.

I-Hydration: I-HPMC iyi-hygroscopic futhi ingamunca amanzi, okuholela ekuvuvukeni nasekukhuphukeni kwe-viscosity. Izinga le-hydration lincike ezintweni ezifana nezinga lokushisa, i-pH, namandla e-ionic yendawo ezungezile. I-hydration idlala indima ebalulekile ekulawuleni ukukhishwa kwezidakamizwa ekwakhiweni kwemithi kanye nokugcina umswakama emikhiqizweni yokudla.

Ukuzwela kwezinga lokushisa:I-HPMCizixazululo zibonisa i-viscosity encike kukushisa, ne-viscosity iyancipha njengoba izinga lokushisa likhuphuka. Kodwa-ke, lokhu kuziphatha kungahluka ngokuya ngezinto ezifana nokugxilwa kwe-polymer nesixazululo se-pH. Ukuzwela kwezinga lokushisa kubalulekile ezinhlelweni ezifana nezinto zokwakha, lapho kuthinta ukusebenza kanye nesikhathi sokusetha.

Ukuzwela Usawoti: Izixazululo ze-HPMC zingabonisa ukuzwela kukasawoti, ngosawoti othile obangela ukuthuthukiswa kwe-viscosity kanye nokunye okubangela ukunciphisa i-viscosity. Lesi simo sibangelwa ukusebenzisana phakathi kwama-molecule e-HPMC nama-ion esixazululweni. Ukuzwela kukasawoti kubaluleke kakhulu ekwenziweni kwemithi kanye nemikhiqizo yokudla lapho okuqukethwe kukasawoti kudinga ukulawulwa ngokucophelela.

Ukuncika Kwezinga Le-Shear: Izakhiwo ze-rheological zezixazululo ze-HPMC zincike kakhulu kuzinga lokugunda elisetshenziswayo. Ngamazinga aphansi e-shear, i-viscosity iphezulu ngenxa yokwanda kwe-molecular entanglement, kanti emazingeni aphezulu okugunda, i-viscosity iyancipha ngenxa yokuncipha kwe-shear. Ukuqonda ukuncika kwezinga le-shear kubalulekile ekuklameni izimo zokucubungula ezinhlelweni ezihlukahlukene.

I-Particle Suspension: I-HPMC ingasebenza njenge-ejenti yokumisa izinhlayiya ekwakhiweni koketshezi ngenxa yokujiya kwayo nokuzinza. Isiza ukuvimbela ukuhlaliswa kwezinhlayiya eziqinile, iqinisekise ukusatshalaliswa okufanayo kanye nokuvumelana emikhiqizweni efana nopende, izinto zokunamathisela, nokumiswa kwemithi.

Ukwakhiwa kweGel:I-HPMCingakha ama-gel ekugxilweni okuphezulu noma phambi kwama-agent axhumanisa njengama-divalent cations. Lawa ma-gel abonisa izakhiwo ze-viscoelastic futhi asetshenziswa ezinsizeni ezifana nokulethwa kwezidakamizwa okulawulwayo, lapho ukukhululwa okuqhubekayo kwezithako ezisebenzayo kuyadingeka.

izici ze-rheological ze-HPMC, okuhlanganisa i-viscosity, i-thixotropy, i-hydration, izinga lokushisa nokuzwela kukasawoti, ukuncika kwesilinganiso se-shear, ukumiswa kwezinhlayiya, nokwakheka kwejeli, kudlala indima ebalulekile ekunqumeni ukusebenza kwayo ezinhlelweni ezihlukahlukene zezimboni. Ukuqonda nokulawula lezi zakhiwo kubalulekile ekuthuthukiseni ukwakheka nokucutshungulwa kwemikhiqizo esekwe ku-HPMC.