I-Hydroxypropyl Methylcellulose (HPMC) iyi-polymer evame ukusetshenziswa kumakhambi, izimonyo, imikhiqizo yokudla, nezinye izinhlelo ezahlukahlukene zezimboni. Kusetshenziswa kabanzi ngenxa yokuthola ukubekeka kwayo, okungeyona ubuthi, kanye nekhono lokuguqula izakhiwo zesinqumo sezixazululo. Kodwa-ke, kubalulekile ukuqonda ukuthi ungasihlakaza kanjani i-HPMC ngempumelelo ukusebenzisa izakhiwo zawo ngokufanele.
Amanzi: I-HPMC incibilikisa kakhulu emanzini, okwenza kube ukukhetha okuthandwayo kwezicelo eziningi. Kodwa-ke, izinga lokuchithwa lingahluka ngokuya ngezinto ezifana nokushisa, ph, kanye nebanga le-HPMC elisetshenzisiwe.
Izixazululo ze-Organic: Izixazululo ezahlukahlukene ze-organic zingancibilikisa i-HPMC ngezengezo ezahlukene. Ezinye izinto ezijwayelekile eziphilayo zifaka:
Ama-Alcohols: I-ISOPPROPANOL (IPA), i-Ethanol, i-Methanol, njll. Lezi zinto zotshwala zivame ukusetshenziswa ezakhiweni semithi futhi zingancibilikisa ngempumelelo i-HPMC.
I-Acetone: I-Acetone iyi-solvent eqinile engancibilikisa i-HPMC kahle.
I-Ethyl Acetate: kungenye i-organic solvent engancipha i-HPMC ngempumelelo.
I-Chloroform: I-Chloroform iyi-solvent enolaka ngokwengeziwe futhi kufanele isetshenziswe ngokuqapha ngenxa yobuthi bayo.
I-Dimethyl Sulfoxide (DMSO): I-DMSO iyi-polar aprotic solvent engancibilikisa amakhompiyutha ahlukahlukene, kufaka phakathi i-HPMC.
I-Propellene Glycol (PG): I-PG ivame ukusetshenziswa njenge-solvent co-solvent ekusungulweni kwemithi. Ingancibilikisa i-HPMC ngempumelelo futhi ivame ukusetshenziswa ngokubambisana namanzi noma amanye ama-solvents.
I-Glycerin: Glycerin, eyaziwa nangokuthi i-Glycerol, iyi-solvent ejwayelekile emikhakheni kanye nezimonyo. Imvamisa isetshenziswa ngokuhlanganiswa namanzi ukuncibilikisa i-HPMC.
I-Polyethylene Glycol (PEG): isikhonkwane yi-polymer ene-solubility enhle kakhulu emanzini nakumanye ama-solvents amaningi ezi-organic. Ingasetshenziswa ukuncibilikisa i-HPMC futhi ivame ukuqashwa ekwakhiweni kokukhishwa okuqhubekayo.
Ama-surfactants: Ama-surfactants athile angasiza ekuchitheni kwe-HPMC ngokunciphisa ukungezwani komhlaba kanye nokwenza ngcono okumanzi. Izibonelo zifaka phakathi phakathi kwama-80, Sodium Lauryl Sulfate (SLS), kanye nePolysorbate 80.
Ama-acid anamandla noma izisekelo: Ngenkathi kungasetshenziswa kaningi ngenxa yokukhathazeka ngokuphepha kanye nokuwohloka okungaba khona kwe-HPMC, ama-acid anamandla (isib. I-Hydrochloric acid) noma izisekelo (isib., Sodium Hydroxide) angancibilikisa i-HPMC ngaphansi kwezimo ezifanele. Kodwa-ke, izimo ze-PH ezedlulele zingaholela ekunciphiseni kwe-polymer.
Izinhlangothi Zokugcina: Ama-ejenti athile anobunzima afana neCyclodextrins angakha izakhiwo ezifakiwe nge-HPMC, esiza ekuchithekeni kwayo futhi athuthukise i-solubity yayo.
Ukushisa: Ngokuvamile, amazinga okushisa aphezulu athuthukisa izinga lokuchithwa kwe-HPMC kuma-solvents njengamanzi. Kodwa-ke, amazinga okushisa aphezulu ngokweqile angalimaza i-polymer, ngakho-ke kubalulekile ukusebenza ngaphakathi kwamazinga okushisa aphephile.
Ukuqashwa Kwemishini: Okushukumisayo noma ukuxuba kungasiza ukuchithwa kwe-HPMC ngokwandisa ukuxhumana phakathi kwe-polymer ne-solvent.
Ubukhulu bezinhlayiyana: I-HPMC eyimpuphu eyimpuphu izoncibilika kalula kunezinhlayiya ezinkulu ngenxa yendawo ekhuphukayo engaphezulu.
Kubalulekile ukuqaphela ukuthi ukukhethwa kwe-solvent kanye nezimo zokuqothula kuncike ohlelweni oluthile kanye nezinto ezifiselekayo zomkhiqizo wokugcina. Ukuvumelana nezinye izithako, ukucatshangelwa kwezokuphepha, nezidingo zokulawula nazo zithonya ukukhethwa kwezixazululo nezindlela zokuqothula. Ngaphezu kwalokho, kubalulekile ukwenza izifundo zokuhambisana nokuhlolwa kokuqina ukuze uqinisekise ukuthi inqubo yokuchitheka ayiyithinteki kabi ikhwalithi noma ukusebenza komkhiqizo wokugcina.
Isikhathi sePosi: Mar-22-2024