Iyini i-HPMC embonini yezemithi?

I-Hydroxypropylmethylcellellellellellulose (HPMC) i-polymer esetshenziswayo esetshenziswa kabanzi embonini yezemithi. Kungokwesigaba se-cellulose ether futhi kususelwa ku-cellulose yemvelo. I-HPMC ihlelwe ngokwelapha iselula nge-oxylene oxide kanye ne-methyl chloride, okuholela kwimibukiso nge-solubity ethuthukisiwe nezinye izakhiwo ezifiselekayo. Le nsizakalo yezemithi isetshenziswa kabanzi ekuthuthukisweni nasekukhiqizeni amafomu ahlukahlukene umthamo, kufaka phakathi amaphilisi, amaphilisi, amalungiselelo we-ophthalmic kanye nezinhlelo zokulethwa kwezidakamizwa ezilawulwayo.

Isingeniso se-hydroxypropyllym methylcellulose:

Ukwakheka kwamakhemikhali nezakhiwo:

I-Hydroxypropylm methylcellulose iyi-semi-zokwenziwa, inert, polymer esolulekayo yamanzi. Isakhiwo saso samakhemikhali sifaka ama-hydroxypropyl kanye namaqembu we-methoxy anamathele emuva kwi-cellulose backbone. Izilinganiso zalezi zinto ezifakiwe zingahluka, okuholele kumabanga ahlukene we-HPMC anezakhiwo ezahlukahlukene. Iphethini yokufakwa esikhundleni esithinta amapharamitha anjengokubona, ukulekelela, kanye nezakhiwo zejeli.

Inqubo Yokukhiqiza:

Ukukhiqizwa kwe-HPMC kufaka phakathi ukusheshisa kwe-cellulose ene-propelene oxide ne-methyl chloride. Izinga lokufakwa esikhundleni (DS) le-Hydroxypropyl kanye namaqembu we-methoxy angalawulwa ngesikhathi sokuhlanganiswa, okuvumela ukuvumelanisa izakhiwo ze-HPMC kwizidingo ezithile zokwakhiwa kwezidakamizwa.

Izicelo embonini yezemithi:

Ama-Binders ngokwakhiwa kwethebhulethi:

I-HPMC isetshenziswa kabanzi njenge-binder ekusungulweni kwethebhulethi. Izakhiwo ezibophayo zisiza ekucindezeleni i-powder emathebutheni aqinile. Ukukhishwa okulawulwa kwezithako ezisebenzayo zemithi (API) kungatholakala ngokusebenzisa amamaki athile e-HPMC ngokubonakala okufanele namazinga wokufaka esikhundleni.

Umenzeli we-Film coating:

I-HPMC isetshenziswa njenge-ejenti ye-coating yefilimu yamathebulethi kanye nama-granules. Inikeza umfaniswano wokuzivikela oshukumisayo athuthukisa ukubukeka, ukunambitha ukuhlanganiswa nokuqina kwamafomu umthamo. Ngaphezu kwalokho, ama-HPMC-based Coatings angalingisa amaphrofayili okukhishwa kwezidakamizwa.

Ukukhishwa okuqinile nokulawulwa:

Isimo se-hydrophilic sale polymer senza ukuthi ilungele ukusetshenziswa ekwakhiweni okusetshenziselwa ukukhishwa. I-matrix ye-HPMC ivumela ukukhishwa kwezidakamizwa okulawulwayo ngaphezulu kwezikhathi ezengeziwe, ukwenza ngcono ukuthotyelwa kweziguli kanye nokunciphisa imvamisa ye-dosing.

Amalungiselelo we-Ophthalmic:

Emakwathini we-ophthalmic, i-HPMC isetshenziselwa ukukhulisa i-viscosity yamaconsi eso, ngaleyo ndlela enikezela ngesikhathi sokuhlala isikhathi eside endaweni ecashile. Lokhu kwenza ngcono ukusebenza kwezidakamizwa kanye nokusebenza kahle kwezokwelapha.

I-Stabilizer Stabilizer:

I-HPMC isetshenziswa njenge-sikhulu ne-stabilizer ekwakhekeni okuqinile futhi okuqinile okufana nama-gels, okhilimu kanye nokumiswa. Inika i-viscosity yalezi zinhlaka futhi ithuthukise izakhiwo zazo ze-khengo.

Izici ezibalulekile ze-HPMC:

I-Solubity:

I-HPMC iyancibilika emanzini futhi yakha ikhambi elicacile nengenamibala. Izinga lokuchithwa lithintwa yizinga lokufakwa esikhundleni kanye nebanga lokubonana.

I-Viscosity:

I-viscosity yezixazululo ze-HPMC ibalulekile ekutholeni ukusebenza kwazo ezinhlelweni ezahlukahlukene. Amamaki ahlukene atholakala nge-visosities ehlukile, evumela ukulawulwa okuqondile kwezakhiwo zeRheological zokwakhiwa.

I-Thermal Gelation:

Amabanga athile e-HPMC ekhombisa izakhiwo ze-thermogelling, ezakha ama-gels emazingeni okushisa aphezulu. Le mpahla isetshenziselwa ukuthuthukisa ukwakheka okubucayi kokushisa.

ukulupheka:

I-HPMC iyahambisana nohlu olubanzi lwe-Exessients yezemithi kanye nama-API, okwenza kube ukukhetha kokuqala kwamakhemikhali. Ayiphenduli noma yehlise izithako ezisebenzayo kakhulu.

IZINSELELE NOKUFUNDA:

I-Hygroscopicity:

I-HPMC i-hygroscopic, okusho ukuthi ithola umswakama emvelweni. Lokhu kuthinta ukuqina nokubukeka kwendlela, ngakho-ke izimo ezifanele zokugcina ziyadingeka.

Ukuhambisana namanye ama-excipients:

Yize ngokuvamile ehambisanayo, amaqembu adinga ukucubungula ukuhambisana kwe-HPMC namanye ama-Excipients ukugwema ukusebenzisana okungaba khona okungathinta ukusebenza kwendlela.

Umphumela ekuchitheni ijika:

Ukukhethwa kwebanga le-HPMC kungathinta kakhulu iphrofayili yokuchitheka yomuthi. Ifomula kufanele ikhethe ngokucophelela ibanga elifanele ukufezekisa izici zokukhishwa oyifunayo.

Ukucatshangelwa Kwabaqondisi:

I-HPMC yamukelwa kabanzi njenge-execipient ephephile nesebenzayo yezemithi. Ihlangabezana namazinga ahlukahlukene alawulayo futhi ifakiwe e-pharmacopoeis emhlabeni jikelele. Abakhiqizi kumele banamathele ezindleleni ezinhle zokukhiqiza (GMP) ukuqinisekisa ikhwalithi nokuvumelana kwemikhiqizo yezemithi equkethe i-HPMC.

Ekuphetheni:

I-Hydroxypropylmethylcellellellellellulose (HPMC), njenge-excipient eguquguqukayo futhi esetshenziswe kabanzi, idlala indima ebalulekile embonini yezemithi. Izakhiwo zayo ezihlukile zikwenza kufanelekile ukusetshenziswa ezinhlobonhlobo zamafomu umthamo, kufaka phakathi amaphilisi, amaphilisi kanye namalungiselelo we-ophthalmic. Amakhemikhali ayazuza ngokukwazi ukuvumelanisa izakhiwo ze-HPMC ukuze ahlangabezane nezidingo ezithile zokuqamba, njengokukhishwa okulawulwayo nokuqina okuthuthukile. Naphezu kwezinselelo ezithile, i-HPMC ihlala isithako esiyisihluthulelo ekwakhiweni kwemikhiqizo esezingeni eliphakeme yemithi, ifaka isandla ekuphepheni nasekusebenzeni kokusebenza kwezidakamizwa eziningi.