Yini i-HPMC eyenziwe ngayo?

I-Hydroxypropyl Methylcellulose (HPMC) iyinhlangano eguquguqukayo ethola izinhlelo zokusebenza ezibanzi kuyo yonke imboni ehlukahlukene, kufaka phakathi amakhemikhali, ukudla, ukwakhiwa kanye nezimonyo. Izakhiwo zayo ezihlukile zikwenza ukuthi kubaluleke kakhulu ekwakhiweni okudinga ukuguqulwa kwe-viscosity, ukwakheka kwamafilimu, ukubopha kanye nokuqina kokuqina. Ukuqonda ukwakheka, inqubo yokukhiqiza, izakhiwo, kanye nokusetshenziswa kwe-HPMC kubalulekile ekusetshenzisweni kwayo okusebenzayo.

1.Isisekelo se-HPMC

I-HPMC iyi-polymer ye-semi-zokwenziwa ethathwe ku-cellulose, okwenzeka ngokwemvelo polysaccharide etholakala ezindongeni zezitshalo. Inqubo yokukhiqiza ifaka ukwelapha i-cellulose nge-Alkali ukukhiqiza i-Alkali Cellulose, ilandelwe yi-exylene oxide ne-methyl chloride. Lokhu kuguqulwa kwamakhemikhali kuholela ekwethulweni kwe-hydroxypropyl kanye ne-methoxy faka esikhundleni se-cellulose backbone, kuthela i-HPMC.

Izinga lokufaka esikhundleni se-hydroxypropyllopyl kanye namaqembu we-methoxy anquma izakhiwo ze-HPMC, kufaka phakathi i-solubity, i-gelation, kanye nezimpawu ezakha amafilimu. Imvamisa, amamaki we-HPMC anamanani aphezulu we-DS abukisa ngokubuyiselwa kwemali emanzini kanye nekhono elithuthukisiwe le-gelation.

2.ProPeries we-HPMC

I-Solubinity yamanzi: I-HPMC iyanyibilika emanzini abandayo, yakha izixazululo ezicacile, ezibonakalayo. I-solubity ingalinganiswa ngokulungisa izinga lokufakwa esikhundleni, isisindo se-molecular, kanye nokushisa.

Ukwakheka kwamafilimu: I-HPMC ingakha amafilimu aguqukayo nawokubonakala emgodini. Lawa mafilimu anezakhiwo ezinhle kakhulu zesithiyo, azibenze zilungele izinhlelo zokusebenza ze-coating kumakhambi kanye nezimboni zokudla.

Ukuguqulwa kwe-VisCosity: I-HPMC ibonisa indlela yokuziphatha ye-Pseudoplastic, lapho ukubonakala kwayo kuncipha ngokukhuphula izinga le-Shear. Le mpahla isetshenziswa ekwakhiweni okuhlukahlukene ukulawula ukusebenza kokugeleza kanye nezimpawu ze-rheological.

Ukuqina okushisayo: I-HPMC ikhombisa ukuqina ebangeni lokushisa elibanzi, okwenza lilungele izinhlelo zokusebenza ezidinga ukucubungula kokushisa noma ukuvezwa kumazinga okushisa aphakeme.

I-Chemical Invertness: I-HPMC i-indert yamakhemikhali, iyahambisana nohlu olubanzi lwezengezo, ama-excipients, nezithako ezisebenzayo ezisetshenziswa kakhulu ekwakhekeni kwemithi nokudla.

I-3.Synthesis ye-HPMC

Ukuhlanganiswa kwe-HPMC kufaka izinyathelo eziningana:

Ukwelashwa kwe-Alkali: I-cellulose iphathwa nge-alkali, efana ne-sodium hydroxide, ukukhiqiza i-alkali cellulose.

I-Eheli: I-Alkali Cellulose iphendulwa nge-propelene oxide ukwethula amaqembu we-hydroxypropyl e-cellulose backbone.

I-methylation: I-Hydroxyproppered cellulose yelashwa futhi nge-methyl chloride ukwethula amaqembu we-methopp, ukuvumela i-HPMC.

Ukuhlanzwa: I-HPMC ephumayo ihlanjululwe ukususa imikhiqizo kanye nokungcola, iqinisekisa ikhwalithi yomkhiqizo nokuvumelana.

4.Izicelo ze-HPMC

Imboni yezemithi: I-HPMC isetshenziswa kabanzi njenge-excipietietical expecietical ngokwakhiwa kwethebulethi, lapho isebenza khona njenge-ejenti ye-binder, ukuqhelelana ne-ament. Iphinde yaqashwa kwizixazululo ze-Ophthalmic, okhilimu abaphezulu, kanye nokumiswa komlomo ngenxa yokubekeka kwayo kanye nezakhiwo ze-mucoadhesive.

Imboni yokudla: Embonini yokudla, i-HPMC isebenza njengesikhulu, i-Stabilizer, kanye ne-emulsifier emikhiqizweni ehlukahlukene, kufaka phakathi amasoso, ukugqoka kanye nezindlela zobisi. Kusetshenziswa futhi ekubhaka kwamahhala kwe-gluten njengomenzeli we-agent kanye nomswakama wokugcina umgcini.

Imboni Yokwakha: I-HPMC isengezo esibalulekile ku-masters osuselwa kusawoti, ama-plasters kanye nama-tile anamathela. Kuthuthukisa ukusebenziseka, ukugcinwa kwamanzi, kanye nokunamathela, okufaka isandla ekusebenzeni okuphelele nokuqina kwezinto zokwakha.

Imikhiqizo yokunakekelwa komuntu siqu: I-HPMC ifakwa kwizimonyo, imikhiqizo ye-skincare, kanye nokwakheka kwezinwele ngokuqina kwayo okwakha ifilimu, ukuqina kanye nokufaka izakhiwo. Inika ukuthungwa okufiselekayo, ukuqina, kanye nezimpawu zokuzwakala ku-lotions, okhilimu kanye nama-gels.

Ukuhlanganiswa nokupakisha: Izigqoko ezisuselwa ku-HPMC zisetshenziselwa amaphilisi wezemithi namaphilisi ukwenza ngcono ukugwinya, ukunambitheka kwamamaski, futhi kunikeze ukuvikelwa komswakama. Amafilimu we-HPMC nawo asetshenziswa ekupakisheni kokudla njengezimbobo ezidliwayo noma izithiyo ngokumelene nomswakama nomoya-mpilo.

I-Hydroxypropyl Methylcellulose (HPMC) iyinhlangano yama-polymer esebenzayo enezicelo ezahlukahlukene kuyo yonke imboni. Inhlanganisela yayo eyingqayizivele yezakhiwo, kufaka phakathi i-solubity yamanzi, ukwakheka kwama-film, ukuguqulwa kwe-viscosity, kanye nokuguqulwa kwamakhemikhali, kwenza ukuba kubaluleke kakhulu emikhakheni, ekudleni, ekudleni nasemikhiqizweni yokunakekelwa komuntu siqu. Ukuqonda ukwakheka, ukuhlanganiswa, izakhiwo, kanye nokusetshenziswa kwe-HPMC kubalulekile kumakhemikhali futhi abakhiqizi bafuna ukuhlanganisa izinzuzo zabo ekuthuthukisweni komkhiqizo kanye nokwenziwa okusha.

Ukubaluleka kuka-HPMC kulele ekuguquguqukeni kwayo, ukusebenza kanye nokunikela ekuthuthukiseni ukusebenza, ukuqina kanye nezimpawu zemikhiqizo ehlukahlukene emikhiqizweni ehlukahlukene emikhakheni ehlukahlukene, okwenza kube isithako esibalulekile ekunikezelweni kwezicelo zanamuhla kanye nezicelo.