Iyini i-hydroxypropyll methylcellulose?

I-Hydroxypropyl methylcellulose (HPMC)Ingabe i-polymer ene-soluble antherses esetshenzisiwe ngokushintsha ama-molecule we-cellulose. Kuhlanganisa izakhiwo zemvelo ze-cellulose ngokusebenza okuguquliwe, ine-solubility enhle yamanzi, ukulungiswa kwamanzi kanye nokulungiswa kwefilimu kanye nezakhiwo ezenziwe ngefilimu, futhi zisetshenziswa kabanzi kwezokwelapha, izimonyo, zokwakha. Le ngxoxo yokuthi i-solvent empeleni idinga ukuhlukanisa izinhlelo zayo nezinhlelo ezithile emikhakheni ehlukene.

Ukwakheka kwamakhemikhali nezakhiwo ze-hydroxypropylylylylylylylykyl

I-HPMC ilungiselelwe ngokwazisa amaqembu amabili angemuva, i-Hydroxypropyl (-ch2ch (oh) CH3) ne-methyl (-ch3), kuyunithi ye-pulvule ye-molecule ye-cellulose. I-cellulose Molecule ngokwayo i-polysaccharide ende ehlanganiswe ama-molecule amaningi ama-β-d-glucose axhunywe ngama-β-1,4-glycosidic bond, neqembu lawo le-hydroxyl (oh) lingathathelwa indawo ngamaqembu ahlukene amakhemikhali, athuthukisa kakhulu izakhiwo zawo.

Ngesikhathi senqubo yokwenza synthesis, i-methylation yenza ama-molecule we-cellulose amaningi i-lipophilic, ngenkathi i-hydroxyproppyylication ithuthukisa i-solubity yayo yamanzi. Ngale ndlela yokuguqulwa okubili, i-HPMC iba yi-polymer eguqukayo engachithwa emanzini.

I-Solubity kanye nomsebenzi we-HPMC

I-HPMC ine-soubelity enhle emanzini, ikakhulukazi emanzini ashisayo. Njengoba izinga lokushisa likhuphuka, izinga lokuchithwa kanye ne-solubity lizokwanda. Kodwa-ke, i-HPMC ngokwayo akuyona "i-solvent" ejwayelekile, kepha isetshenziswa njenge-solvent noma isikhunzi. Ku-liquid, kungakha isixazululo se-colloidal ngokuxhumana nama-molecule amanzi, ngaleyo ndlela kulungiswe i-viscosity kanye nomlomo wesisombululo.

Yize i-HPMC ingachithwa emanzini, ayinazo izakhiwo ze- "solvent" ngomqondo wendabuko. Izixazululo zivame ukuncibilika ezinye izinto, njengamanzi, ama-alcohols, ama-ketones noma amanye ama-solvents ezi-organic. Ukuchithwa kwe-HPMC uqobo emanzini kungaphezulu kwengxenye esebenzayo yokuqina, ukugcinwa kwama-golling kanye nefilimu.

Izinkambu zohlelo lokusebenza ze-HPMC

I-Medical Field: I-HPMC ivame ukusetshenziswa njenge-excipont for izidakamizwa, ikakhulukazi lapho kulungiswa amafomu omthamo womlomo (njengamathebulethi kanye nama-caplule), asetshenziselwa ukuqina, ikakhulukazi ama-caplules kanye neminye imisebenzi. Kungathuthukisa ama-bioavailability of izidakamizwa futhi kusetshenziswa futhi kumalungiselelo wokukhulula okuqhubekayo okusiza ukulawula ukukhishwa kwezidakamizwa.

Inkambu yezimonyo Indima yayo kwizimonyo ikakhulukazi ukwandisa ukuqina kanye nokuthungwa komkhiqizo futhi kwenze kube ntofontofo kakhudlwana.

Inkambu Yokwakha: Embonini yezokwakha, i-HPMC isetshenziswa njengomuntu omkhulu futhi ihlakazekile ku-usimende, udaka owomile, upende neminye imikhiqizo. Kungakhuphula ukubonwa kopende, kuthuthukise ukusebenza kokwakha futhi kwandise isikhathi sokwakha.

Inkambu yokudla: I-HPMC isetshenziswa njengesengezo sokudla, ikakhulukazi esisetshenziselwa ukuqina, ukukhuphula kanye nokwenza ngcono ukunambitheka, futhi kuvame ukutholakala ekudleni okunamafutha amancane, amaswidi kanye no-ayisikhilimu. Ngaphezu kwalokho, ingasetshenziswa futhi ukuthuthukisa ukuthungwa, ukunambitha kanye nokusha kokudla.

Isicelo njenge-solvent

Kwezinye izinqubo ezithile zokulungiselela, i-HPMC ingabuye isetshenziswe njengengxenye esizayo ye-solvent. Isibonelo, embonini yezemithi, i-solubity ye-HPMC ikuvumela ukuthi isetshenziswe njenge-diliount noma i-solubilizer kumalungiselelo wezidakamizwa, ikakhulukazi kumalungiselelo athile owuketshezi, lapho kungasiza khona ngempumelelo ukuncibilikisa izidakamizwa futhi wakhe isixazululo esifanayo.

Kwezinye izigqoko ezisekelwe emanzini,I-HPMCIngase futhi isetshenziswe njenge-ejenti yokusizakala kwe-solvent ukuthuthukisa izakhiwo ze-bheological kanye nokusebenza kwe-coating, yize i-solvent eyinhloko ku-coating imvamisa amanzi noma i-organic solvent.

Yize i-HPMC ingachithwa emanzini amaningi okusiza ukwakha i-colloid noma isixazululo futhi yandise ukuvuleka noketshezi lwesixazululo, ngokwayo ayithathwa njenge-solvent ngomqondo wendabuko. Esikhundleni salokho, kuvame ukusetshenziswa njengento esebenzayo efana nesikhulu, umenzeli we-gelling, kanye ne-ejenti eyakha ifilimu. Inezinhlobonhlobo zezicelo ezinkambeni ezahlukahlukene, ikakhulukazi ezimbonini zezemithi, zokugcoba, zokudla, nasezimbonini zokwakha. Ngakho-ke, lapho uyaqonda iqhaza nezakhiwo ze-HPMC, kufanele kubhekwe njenge-polymer esebenzayo yamanzi encibilikisiwe kunokuba kube ne-solvent elula.