Ithini indawo yokuncibilika ye-HPMC polymer?

I-HPMC (Hydroxypropyl Methylcellulose) iyinhlanganisela ye-polymer encibilika emanzini esetshenziswa kabanzi kwezemithi, ukudla, ukwakhiwa, izimonyo nezinye izimboni. I-HPMC iwumphumela we-semi-synthetic cellulose etholwe ngokuguqulwa kwamakhemikhali e-cellulose yemvelo, futhi ivamise ukusetshenziswa njenge-thickener, stabilizer, emulsifier kanye ne-adhesive.

Izakhiwo zomzimba ze-HPMC

Iphuzu lokuncibilika le-HPMC liyinkimbinkimbi kakhulu ngoba indawo yayo yokuncibilika ayibonakali njengezinto ezijwayelekile zekristalu. Indawo yayo yokuncibilika ithintwa ukwakheka kwamangqamuzana, isisindo samangqamuzana kanye nezinga lokushintshwa kwe-hydroxypropyl namaqembu e-methyl, ngakho-ke ingahluka ngokuya ngomkhiqizo othize we-HPMC. Ngokuvamile, njenge-polymer encibilika emanzini, i-HPMC ayinayo indawo encibilikayo ecacile nefanayo, kodwa iyathamba futhi ibole phakathi kwebanga elithile lokushisa.

Ibanga lephoyinti lokuncibilika

Ukuziphatha okushisayo kwe-AnxinCel®HPMC kuyinkimbinkimbi kakhulu, futhi ukuziphatha kwayo kokubola okushisayo kuvame ukufundwa ngokuhlaziywa kwe-thermogravimetric (TGA). Kusukela ezincwadini, kungatholakala ukuthi ibanga lokuncibilika le-HPMC liphakathi kwama-200.°C futhi 300°C, kodwa lobu bubanzi abuyimele indawo yangempela yokuncibilika yayo yonke imikhiqizo ye-HPMC. Izinhlobo ezahlukene zemikhiqizo ye-HPMC zingase zibe namaphoyinti ahlukene okuncibilika kanye nokuzinza okushisayo ngenxa yezici ezifana nesisindo samangqamuzana, idigri ye-ethoxylation (i-degree of substitution), degree of hydroxypropylation (degree of substitution).

I-HPMC enesisindo esiphansi samangqamuzana: Imvamisa iyancibilika noma ithambe emazingeni okushisa aphansi, futhi ingase iqale ukushibilika noma incibilike cishe ngama-200.°C.

Isisindo samangqamuzana aphezulu I-HPMC: Ama-polymer e-HPMC anesisindo esiphezulu se-molecular angase adinge amazinga okushisa aphezulu ukuze ancibilike noma athambe ngenxa yamaketanga awo amangqamuzana amade, futhi ngokuvamile aqala ukubola nokuncibilika phakathi kuka-250.°C futhi 300°C.

Izinto ezithinta indawo encibilikayo ye-HPMC

Isisindo samangqamuzana: Isisindo samangqamuzana e-HPMC sinomthelela omkhulu endaweni yaso yokuncibilika. Isisindo samangqamuzana aphansi ngokuvamile sisho izinga lokushisa eliphansi lokuncibilika, kuyilapho isisindo samangqamuzana esiphezulu singaholela endaweni ephakeme yokuncibilika.

Izinga lokushintsha: Izinga le-hydroxypropylation (okungukuthi isilinganiso sokushintsha se-hydroxypropyl ku-molecule) kanye nezinga le-methylation (okungukuthi isilinganiso sokushintsha se-methyl ku-molecule) ye-HPMC nakho kuthinta indawo yayo yokuncibilika. Ngokuvamile, izinga eliphezulu lokushintsha likhuphula ukunyibilika kwe-HPMC futhi kunciphisa indawo yayo yokuncibilika.

Okuqukethwe komswakamo: Njengempahla encibilika emanzini, indawo encibilikayo ye-HPMC nayo ithintwa umswakama wayo. I-HPMC enomswakama ophezulu ingase ingene emanzini noma ihlakazeke ingxenye, okuholela ekushintsheni kwezinga lokushisa lokubola okushisayo.

Ukuzinza okushisayo kanye nezinga lokushisa lokubola kwe-HPMC

Nakuba i-HPMC ingenayo indawo eqinile yokuncibilika, ukuzinza kwayo okushisayo kuyinkomba yokusebenza okubalulekile. Ngokusho kwedatha yokuhlaziywa kwe-thermogravimetric (TGA), i-HPMC ivamise ukuqala ukubola ebangeni lokushisa elingu-250.°C kuya ku-300°C. Izinga lokushisa elithile lokubola lincike esisindweni samangqamuzana, izinga lokushintsha kanye nezinye izici zomzimba namakhemikhali ze-HPMC.

Ukwelashwa okushisayo ezinhlelweni ze-HPMC

Ezinhlelweni zokusebenza, indawo yokuncibilika nokuzinza kokushisa kwe-HPMC kubaluleke kakhulu. Isibonelo, embonini yezemithi, i-HPMC ivamise ukusetshenziswa njengezinto ezisetshenziswayo zamaphilisi, okokumbozwa kwefilimu, nabathwali bemithi ekhishwa isikhathi eside. Kulezi zinhlelo zokusebenza, ukuzinza okushisayo kwe-HPMC kudinga ukuhlangabezana nezidingo zokucubungula izinga lokushisa, ngakho-ke ukuqonda ukuziphatha okushisayo kanye nohlu lwephoyinti lokuncibilika le-HPMC kubalulekile ekulawuleni inqubo yokukhiqiza.

Emkhakheni wokwakha, i-AnxinCel®HPMC ivamise ukusetshenziswa njenge-thickener odakeni olomile, okokunamathela kanye nezinamatheliso. Kulezi zinhlelo zokusebenza, ukuzinza okushisayo kwe-HPMC nakho kudinga ukuba phakathi kwebanga elithile ukuze kuqinisekiswe ukuthi akuboli ngesikhathi sokwakhiwa.

I-HPMC, njenge-polymer material, ayinayo indawo encibilikayo engaguquki, kodwa ibonisa izici zokuthambisa kanye ne-pyrolysis ngaphakathi kwebanga elithile lokushisa. Ibanga lephoyinti layo lokuncibilika ngokuvamile liphakathi kuka-200°C futhi 300°C, kanye nephuzu elithile lokuncibilika lincike ezintweni ezifana nesisindo samangqamuzana, idigri ye-hydroxypropylation, idigri ye-methylation, nokuqukethwe komswakama we-HPMC. Ezimweni ezihlukene zohlelo lokusebenza, ukuqonda lezi zakhiwo ezishisayo kubalulekile ekulungiseleleni nasekusetshenzisweni kwazo.