I-Film coaties iyinqubo ebalulekile ekukhiqizweni kwemithi, lapho ungqimba oluncane lwe-polymer lusetshenziswa ebusweni bamathebulethi noma amaphilisi. Le nhlanganisela isebenza ngezinhloso ezahlukahlukene, kufaka phakathi ukuthuthukisa ukubukeka, ukunambitheka, ukuvikela isithako sezemithi esisebenzayo (API), ukulawula ukukhishwa, kanye nokwenza lula ukugwinya. I-Hydroxypropyl Methylcellulose (HPMC) ingenye yama-polymers asetshenziswa kakhulu e-film coating ngenxa yezindawo zayo eziguquguqukayo ngenxa yezakhiwo zayo eziguquguqukayo.
1.Propeties we-HPMC:
I-Hydroxypropyl Methylcellulose (HPMC) iyi-polymer yokwenziwa ese-cellulose. Kuboniswa yi-solubility yayo yamanzi, ikhono elakha amafilimu, kanye nokuvumelana okuhle kakhulu ngezithako ezahlukahlukene zemithi. Izakhiwo ze-HPMC zingalinganiswa ngokushintsha amapharamitha anjengesisindo se-molecular, degree yokufaka esikhundleni, kanye nokubonakala.
Ikhono elenziwayo lefilimu: I-HPMC inayo izakhiwo ezinhle kakhulu zefilimu, inika amandla ukwakheka komfaniswano kanye nokuhlanganiswa okubushelelezi ebusweni bezindlela zama-dosage zemithi.
I-solubity yamanzi: I-HPMC ikhombisa i-soubity yamanzi, ukuvumela ukuchithwa kwe-polymer kwizisombululo zamanzi ngesikhathi senqubo yokuhlanganisa. Le mpahla iqinisekisa ukuhanjiswa okufanayo kwe-polymer futhi kusiza ukwakheka kwe-homogeneous coating ungqimba.
I-Adhesion: I-HPMC ikhombisa ukunamathela okuhle ebusweni bamathebulethi noma amaphilisi, okuholela ekuhlolweni okuqinile okunamathela kahle ku-substrate.
Izakhiwo ezibanda: I-HPMC ihlinzeka ngesithiyo ekulweni nezici zezemvelo ezifana nomswakama, umoya-mpilo, nokukhanya, ngaleyo ndlela ukuvikela ubuqotho befomu lomthamo kanye nokwenza ngcono ukuqina.
Ukucatshangelwa kwe-2.Cmation:
Ekwakheni isixazululo se-filming-coating sisebenzisa i-HPMC, kudingeka kubhekwe izinto eziningana ukuze uzuze izici zokufinyelela kanye nokusebenza okufisayo.
Ukuhlushwa kwe-polymer: Ukuhlushwa kwe-HPMC kusisombululo se-coating kuthonya ubukhulu kanye nezakhiwo zemishini zefilimu. Umphumela wokugxila okuphezulu kwe-polymer ku-Swerer Coatings enezakhiwo ezivinjelwe ezithuthukisiwe.
Amapulasitiki: Isengezo samapulasitiki afana nePolyethylene Glycol (PEG) noma i-Porylene Glycol (PG) ingathuthukisa ukuguquguquka nokuqina kokuhlangana, okwenza kube ngaphansi kwe-brittle.
I-Solvents: Ukukhetha ama-solvents afanelekile kubalulekile ukuze kuqinisekiswe ukuthi i-solubity ye-HPMC kanye nokwakheka kwefilimu okufanele. Izixazululo ezijwayelekile zifaka amanzi, i-ethanol, i-sopropanol, kanye nokuhlanganiswa kwayo.
Ama-pigments kanye nama-opacifiers: Ukufakwa kwemibala kanye nama-opacifiers kufomethi yokuhlanganisa kungadlulisela umbala, ukuthuthukisa ukubukeka, futhi kunikeze ukuvikela okukhanyayo kwezidakamizwa ezibucayi.
3.Izincazelo ze-HPMC ku-film coating:
Ama-coatings asuselwa ku-HPMC athola izicelo ezibanzi ezimbonini zezemithi kanye nezezimali ezinobudlova ngenxa yokusebenza kwawo kanye nokufaneleka kwezindlela ezahlukahlukene zamadosamu.
Ukukhishwa kwemali okusheshayo: Izimbobo ze-HPMC zingasetshenziswa ukuhlinzeka ngokukhululwa kwezidakamizwa ngokushesha ngokulawula ukuhlukaniswa kanye namanani amaphilisi noma amaphilisi.
Izigqoko zokukhishwa ezilungisiwe: Ukusungulwa okusekwe ku-HPMC kuvame ukuqashwa kumafomu okukhishwa kwemali okushintshiwe, kufaka phakathi ukwakheka okunwetshiwe kanye nokwakheka okufakiwe. Ngokushintsha i-viscosity nobukhulu bokuhlanganiswa, iphrofayili yokukhishwa kwesidakamizwa ingahle ifanelwe ukufeza ukukhishwa okuqhubekayo noma okuhlosiwe.
Ukunambitha Ukulinganisa: Izimbozo ze-HPMC zingavimba ukunambitheka okungathandeki kwezidakamizwa, ngcono ukuhambisana kweziguli nokwamukelekayo kwamafomu wamadosi omlomo.
Ukuvikelwa komswakama: Izimbobo ze-HPMC zinikeza ukuvikela okusebenzayo komswakama, ikakhulukazi ukuthola izidakamizwa ezihlanganisiwe ezithambekele ekuchayweni okonakele ekuchayweni umswakama.
Ukuthuthukiswa kokuqina: Izimbobo ze-HPMC zinikeza isithiyo esivikelayo ekulweni nezici zezemvelo, ngaleyo ndlela zithuthukise ukuqina kanye neshelufu-impilo yemikhiqizo yezemithi.
I-Hydroxypropylm methylcellulose (HPMC) idlala indima ebalulekile kwizicelo ze-film coating emkhakheni wezemithi. Izakhiwo zayo ezihlukile, kufaka phakathi ikhono elakha amafilimu, i-solubility yamanzi, ukunamathela, kanye nezindawo ezinesithiyo, kwenze kube yindlela efanelekile yokwakha izigqoko ezihlukile ukusebenza. Ngokuqonda ukucatshangelwa okwakheka kanye nokusetshenziswa kwe-HPMC kwi-film coating, abakhiqizi bemithi bangathuthukisa amafomu ama-dosage ngokusebenza okuthuthukisiwe, ukuqina, kanye nokwamukela isiguli.
Isikhathi Sokuthumela: Mar-07-2024