I-Hydroxypropyl methylcellulose (HPMC)Ingabe ifomu eliguqulwe ngamakhemikhali le-cellulose elisetshenziswa kabanzi ezinhlobonhlobo zezimboni ezinjengemithi, ukukhiqizwa kokudla, kanye nokwakha. Kuyindawo eguquguqukayo, evame ukusetshenziswa njengomuntu omkhulu, i-binder, umenzeli wefilimu, ne-stabilizer. Kodwa-ke, ayinayo "inombolo ye-serial" ethile ngomqondo wendabuko, njengomkhiqizo noma inombolo yengxenye ongayithola kwezinye izimo zokukhiqiza. Esikhundleni salokho, i-HPMC ikhonjwe yisakhiwo sayo samakhemikhali kanye nezimpawu eziningi, njengezinga lokufakwa esikhundleni kanye nokubonakala.
Imininingwane Ejwayelekile ngeHydroxypropyllym Methylcellulose (HPMC)
Isakhiwo samakhemikhali: I-HPMC yenziwa ngokuguqula amakhemikhali ngokufaka amaqembu okufakwa esikhundleni se-hydroxyl (oh) ngama-hydroxypropyl kanye namaqembu we-methyl. Ukufakwa kabusha kuguqula izakhiwo ze-cellulose, okwenza kuncibilikeke emanzini futhi zikunikeze izakhiwo zayo ezihlukile njengekhono elenziwe ngefilimu, amandla okubopha, kanye nekhono lokugcina umswakama.
Izikhombi ezijwayelekile nokuqamba
Ukukhonjwa kwe-hydroxypropyllylyll methyllellulose kuvame ukuthembela ezinhlotsheni ezahlukahlukene zokuqamba amagama achaza ukwakheka kwawo kwamakhemikhali kanye nezakhiwo:
Inombolo ye-CAS:
Isevisi yamakhemikhali (CACHERCTS STIVETS (CAS) inika isikhombi esiyingqayizivele kuyo yonke into yamakhemikhali. Inombolo ye-CAS ye-Hydroxypropylllylylyly methylcellulose ingu-9004-65-3. Le yinombolo esekiwe esetshenziswe ngamakhemikhali, abahlinzeki, kanye nemizimba yokulawula ukubhekisa entweni.
Ama-inchi futhi amamatheke amakhodi:
I-Inchi (Isikhombi Samakhemikhali Wamakhemikhali Esijwayelekile senye indlela yokumelela ukwakheka kwamakhemikhali kwento. I-HPMC ingaba nentambo ende ye-inchi emele isakhiwo sayo samangqamuzana ngefomethi endisiwe.
Ukumamatheka (uhlelo lokufakwa komugqa olwenziwe lula) ngolunye uhlelo olusetshenziselwa ukumela ama-molecule ngendlela yombhalo. I-HPMC nayo inekhodi yokumamatheka ehambisanayo, yize bekungaba yinkimbinkimbi kakhulu ngenxa yemvelo enkulu nehlukahlukene yesakhiwo sayo.
Imininingwane Yomkhiqizo:
Emakethe yezentengiselwano, i-HPMC ivame ukukhonjwa izinombolo zomkhiqizo, ezingahluka ngomenzi. Isibonelo, umphakeli angaba nebanga elifana ne-HPMC K4M noma i-HPMC E15. Lezi zihlonzi zivame ukubhekisela ekubonakaleni kwe-polymer ngesixazululo, esinqunywa ngezinga le-methylation kanye ne-hydroxypropylation kanye nesisindo se-molecular.
Amabanga ajwayelekile we-hydroxypropylllyllose (hpmc)
Izici ze-Hydroxypropylllylyl methyllellose ziyehluka ngokuya ngezinga lokufaka esikhundleni se-methyl kanye ne-hydroxypropyly, kanye nesisindo se-molecular. Lokhu kwehluka kunquma ukubonakala kwe-HPMC kanye ne-solubity emanzini, okuthinta ukusetshenziswa kwalo kwizimboni ezahlukahlukene.
Ngezansi kwethebula elichaza amamaki ahlukene we-hydroxypropyllylylylylyly:
| Khuphuka | I-Viscosity (CP ngesisombululo esingu-2%) | Izinja | Ukufanisa |
| Hpmc k4m | I-4000 - 6000 cp | I-TABLETERATE TOBTER Tablet, Imboni Yokudla, Yokwakhiwa (Adhesives) | Ibanga eliphakathi le-Viscosity, elivame ukusetshenziswa ekwakhiweni kwamathebhulethi ngomlomo. |
| I-HPMC K100M | 100,000 - 150,000 cp | Ukwakheka okukhishwe okulawulwayo emikhakheni, ekwakheni nasekuhlotsheni kopende | I-viscosity ephezulu, enhle kakhulu ekukhishweni kwezidakamizwa. |
| I-HPMC E4M | 3000 - 4500 CP | Izimonyo, izindlu zangasese, ukucubungula ukudla, ukunamathela, kanye nezimbobo | Incibilika emanzini abandayo, asetshenziswa emikhiqizweni yokunakekelwa komuntu kanye nezinto zokudla. |
| I-HPMC E15 | I-15,000 CP | I-ejenti yokuqina ngopende, ukumboza, ukudla, kanye nemithi yezemithi | I-viscosity ephezulu, incibilika emanzini abandayo, asetshenziswa emikhiqizweni yezimboni nezemithi. |
| Hpmc m4c | I-4000 - 6000 cp | Imboni yokudla nokuphuza njenge-stabilizer, emikhakheni njenge-binder | I-Viscosity Elinganiselayo, evame ukusetshenziswa njengomkhulu ekudleni okusetshenzwe. |
| I-HPMC 2910 | I-3000 - 6000 cp | Izimonyo (okhilimu, i-lotions), ukudla (confectionery), amakhemikhali (amaphilisi, ukumboza) | Elinye lamamaki ajwayelekile kakhulu, asetshenziswa njenge-ejenti yokuqina kanye nokuqina. |
| I-HPMC 2208 | I-5000 - 15000 cp | Isetshenziswa ekusungulweni kosimende kanye nokwenza ama-plaster, izindwangu, izimbotshana zamaphepha | Ilungele izinhlelo zokusebenza ezidinga izakhiwo ezinhle kakhulu zefilimu. |
Ukwakheka okuningiliziwe kanye nezindawo ze-HPMC
Izakhiwo ezibonakalayo ze-hydroxypropyllylylylylylylylylyllellulose zincike kakhulu ngobungako bokufaka esikhundleni samaqembu ama-hydroxyl ku-molecule ye-cellulose. Nazi izakhiwo ezinkulu:
Degree of substitution (DS):
Lokhu kusho ukuthi mangaki amaqembu ama-hydroxyl e-cellulose afakwe esikhundleni samaqembu we-methyl noma ama-hydroxypropyl. Izinga lokufaka esikhundleni lithinta i-solubility ye-HPMC emanzini, ukubonakala kwalo, namandla ayo okwenza amafilimu. I-DS ejwayelekile yamabanga we-HPMC asuka ku-1.4 kuye ku-2.2, ngokuya ngebanga.
I-Viscosity:
Amabanga we-HPMC ahlukaniswe ngokususelwa ekubonakaleni kwabo lapho echithwe emanzini. Isisindo esiphakeme kakhulu kanye nezinga lokufaka esikhundleni, kuphakama okubonakalayo. Isibonelo, i-HPMC K100M (ngohla oluphezulu lwe-viscosity) ivame ukusetshenziswa ekwakhiweni kwezidakamizwa okulawulwa okulawulwayo, kanti amabanga aphansi aphansi afana ne-HPMC K4m esetshenziselwa ama-tablet ama-bundeb kanye nezicelo zokudla.
I-Solubity yamanzi:
I-HPMC iyanyibilika emanzini futhi yakha into efana nejeli lapho ichithwa, kepha izinga lokushisa kanye ne-ph lingathonya i-solubity yayo. Isibonelo, emanzini abandayo, kuncibilika ngokushesha, kepha i-soubelity yayo ingancishiswa emanzini ashisayo, ikakhulukazi ekugxileni okuphezulu.
Ikhono elenziwa ngefilimu:
Enye yezinto ezibalulekile ze-hydroxypropyllylylylylylykylwose yikhono layo lokwakha ifilimu eliguqukayo. Le mpahla yenza kube lula ukusetshenziswa kuma-tablet coatings, lapho ihlinzeka khona indawo ebushelelezi, enikelwa ngokulawulwa. Kuyasiza futhi embonini yokudla ukuze uthuthukise ukuthungwa nempilo yeshelufu.
I-Gelation:
Ngokugxila okuthile kanye namazinga okushisa, i-HPMC ingakha ama-gels. Le mpahla inenzuzo ekwakhiweni kwemithi, lapho isetshenziselwa ukudala amasistimu wokukhishwa okulawulwayo.
Izicelo ze-hydroxypropylm methylcellulose
Imboni Yezemithi:
I-HPMC isetshenziswa njenge-binder ngokwakhiwa kwethebhulethi, ikakhulukazi ezinhlelweni ezeluliwe futhi ezilawulwa ezilawulwayo. Iphinde isebenze njenge-ejenti ehlanganayo yamathebulethi kanye nama-capsule okulawula ukukhishwa kwesithako esisebenzayo. Amandla awo okwenza amafilimu aqinile namaGels alungele izinhlelo zokulethwa kwezidakamizwa.
Imboni yokudla
Embonini yokudla, i-HPMC isetshenziswa njenge-ejenti yokuqina, i-emulsifier, ne-stabilizer emikhiqizweni ehlukahlukene, kufaka phakathi amasoso, ukugqoka kanye nezimpahla ezibhakiwe. Kuyasiza ukuthuthukisa ukuthungwa kanye nokunweba impilo eshalofini ngokunciphisa ukulahleka komswakama.
Izimonyo nokunakekelwa komuntu siqu:
I-HPMC isetshenziswa kabanzi kwizimonyo, lapho isebenza khona njengesikhulu nokuqina kumakhilimu, ama-lotion, ama-shampoos kanye neminye imikhiqizo yokunakekelwa komuntu siqu. Amandla awo okwenza isakhiwo sejeli asebenza ngokukhethekile kulezi zinhlelo zokusebenza.
Imboni Yokwakha:
Embonini yezokwakha, ikakhulukazi ukwakheka kosimende kanye nokwenza udaka, i-HPMC isetshenziswa njenge-ejenti yokugcina amanzi. Kuyasiza ukuthuthukisa ukusebenza futhi kuthuthukise izakhiwo ezibophayo zezinto zokwakha.
Ezinye izinhlelo zokusebenza:
I-HPMC nayo iqashwa embonini yezindwangu, ukumbona amaphepha, ngisho nasekukhiqizweni kwamafilimu angenakuphikwa.
I-Hydroxypropyl methylcellulose (HPMC)Ikhompiyutha eguquguqukayo esetshenziswa kakhulu esetshenziselwa izimboni eziningi ngenxa yezakhiwo zayo ezihlukile njengamandla akha amafilimu, amandla okuqina, nokugcinwa kwamanzi. Ngenkathi ingenayo "inombolo ye-serial" emcabangweni ojwayelekile, ikhonjwa yizikhombi zamakhemikhali ezifana nenombolo yayo ye-CAS (9004-65-3) namamaki aqondene nomkhiqizo (isib. I-HPMC K100M, HPMC E4M). Uhla oluhlukahlukene lwamabanga we-HPMC atholakalayo aqinisekisa ukusebenza kwalo emikhakheni ehlukene, kusuka emikhakheni kuya ekudleni, izimonyo kanye nokwakha.
Isikhathi sePosi: Mar-21-2025