I-Hydroxypropylmethylcellellellellellulose (HPMC) i-cellulose derivative esetshenziswa kakhulu kwizimboni ezahlukahlukene, kufaka phakathi amakhemikhali, ukwakhiwa nokudla. I-viscosity yayo ingahluka ngokuya ngezinto ezinjengesisindo sayo samangqamuzana, izinga lokufaka esikhundleni sokufakwa esikhundleni, kanye nokuhlushwa kwesixazululo.
Isingeniso se-hydroxypropylm methylcellulose (HPMC)
I-Hydroxypropyl Methylcellulose iyi-polymer yokwenziwa esezingeni elitholwe ukuguqulwa kwamakhemikhali kwe-cellulose. Ngenxa yezakhiwo zayo ezihlukile, kusetshenziswa kabanzi njengomuntu omkhulu, i-ejenti ye-gelling, ifilimu langaphambili kanye ne-stibilizer kuzicelo ezahlukahlukene.
Ukwakheka kwamangqamuzana nokwakheka
I-HPMC iqukethe umgogodla we-cellulose enezinto ezinama-hydroxypropyl kanye ne-methoxy substitunts. Izinga lokufaka esikhundleni (DS) lisho inani eliphakathi lokufakwa esikhundleni kweyunithi ngayinye ye-Anhydroglucose eCellulose Chain. Inani elithile le-DS lithinta izakhiwo zomzimba nezamakhemikhali ze-HPMC.
I-HPMC IVIVOSISIT
I-Viscosity iyipharamitha ebalulekile ye-HPMC, ikakhulukazi kuzinhlelo zokusebenza ezisebenzisa izakhiwo zayo zokuqina kanye nama-gelling.
I-viscosity yezixazululo ze-HPMC ithintwa yizinto eziningi:
1. Isisindo molecular
Isisindo se-molecular se-HPMC sithinta ukubonakala kwaso. Ngokuvamile, ama-HPMC aphezulu we-molecular HPMC avame ukukhiqiza izixazululo eziphakeme ze-viscosity. Kunamabanga ahlukene we-HPMC emakethe, ngalinye linebanga laso eliqokiwe lesisindo se-molecular.
2. Izinga lokufaka esikhundleni (DS)
Amanani we-DS we-Hydroxypropyl kanye namaqembu we-methoxy athinta i-solubity kanye nokubonakala kwe-HPMC. Amanani aphezulu we-DS ngokuvamile aphumela ekukhulisweni kwamanzi okuningana kanye nezixazululo ezinkulu.
3. Ukugxila
Ukuhlushwa kwe-HPMC kusixazululo kuyinto ebalulekile ethinta i-viscosity. Njengoba ukuhlukunyezwa kukhuphuka, ukubonakala kuvame ukukhuphuka. Lobuhlobo buvame ukuchazwa yi-krieger-Dougherty equation.
4. Ukushisa
Ukushisa futhi kuthinta ukubonakala kwezixazululo ze-HPMC. Ngokuvamile, ukubonakala kuyancipha njengokuthi izinga lokushisa lenyuka.
Izindawo zohlelo lokusebenza
I-Pharmaceuticals: I-HPMC ivame ukusetshenziswa ekwakhiweni kwemithi, kufaka phakathi amaphilisi kanye nezixazululo ze-ophthalmic, lapho ukukhishwa okulawulwayo nokubonakala kubalulekile.
Ukwakha: Embonini yezokwakha, i-HPMC isetshenziswa njengesikhulu emikhiqizweni esekwe kuthusi ukwenza ngcono ukusebenza nokugcinwa kwamanzi.
Imboni yokudla: I-HPMC isetshenziswa njengesikhudlwana, i-Stabilizer kanye ne-emulsifier kuzinhlelo zokusebenza zokudla.
I-viscoxyprosil methylcellulose iyindawo eyinkimbinkimbi ethintwa yizinto eziningi ezifana nesisindo se-molecular, degree yokufaka esikhundleni, ukugxila kanye nokushisa. Amabanga ahlukene we-HPMC ayatholakala ukuze avumelane nezinhlelo ezithile, futhi abakhiqizi bahlinzeka ngemininingwane yezobuchwepheshe echaza uhla lwe-viscosity yebanga ngalinye ngaphansi kwezimo ezahlukahlukene ngaphansi kwezimo ezahlukahlukene. Abaphenyi namaqembu amathimu kufanele babheke lezi zinto zokuvumelanisa izakhiwo ze-HPMC ukuze zihlangabezane nezidingo zezinhlelo zazo ezihlosiwe.
Isikhathi Seposi: Jan-20-2024