Yisiphi impahla ebonakalayo ye-hydroxypropyllop methylcellulose ikhambi elinamanzi?

I-Hydroxypropyl methylcellulose (HPMC)Ingabe impahla ene-polymer ene-polymer esetshenziswa kabanzi eMkhemeni, ekwakheni, ekudleni, izimonyo kanye nezinye izinkambu. Impahla yayo yokubonakayo iyipharamitha ebalulekile ukukala ukusebenza kwayo ezimbongini ngaphansi kwezindawo ezahlukahlukene. Ukuqonda impahla ye-viscosity yekhambi le-HPMC elinamanzi kusisiza ukuthi siqonde kangcono ukusebenza kwaso nokusebenza kwalo ezinhlangeni ezahlukahlukene.

1. Isakhiwo samakhemikhali nezakhiwo ze-HPMC

I-HPMC itholakala ngokuguqulwa kwamakhemikhali kwe-cellulose yemvelo, eyakhiwa ikakhulukazi nge-hydroxypropylication kanye ne-methylation yama-molecule we-cellulose. Ngokwakheka kwamakhemikhali ye-HPMC, ukwethulwa kwe-methyl (-Och₃) kanye neHydroxypropyll (-Coch₂chohchch) Amaqembu enza ukuba ancibilike ngamanzi futhi inekhono elihle lokulungiswa kwe-viscosity. Ukusebenza kwe-viscosity yesisombululo salo esinamanzi ezigxilini nasezingeni eliphakeme kuthintwa yizici eziningi ezinjengesisindo se-molecular, degree yokufaka esikhundleni, ukugxilisa isixazululo, njll.

2. Ubudlelwano phakathi kwe-viscosity kanye nokuhlushwa

I-Viscosity yekhambi le-Dicencel®HPMC livame ukukhuphuka ngokuhlushwa okwandayo. Lokhu kungenxa yokuthi ekugxilisweni okuphezulu, ukuxhumana phakathi kwama-molecule kuyathuthukiswa, okuholela ekuphikeni okuqhubekayo okuqhubekayo. Kodwa-ke, i-solubity kanye ne-viscosity izici ze-HPMC emanzini nazo zithinteka isisindo se-molecular. I-HPMC enesisindo esiphakeme samangqamuzana imvamisa ibonisa ukubonakala okuphezulu, ngenkathi isisindo samangqamuzana aphansi siphansi.

Ekugxileni okuphansi: Isixazululo se-HPMC sibonisa ukubonakala okuphansi kokugxila okuphansi (okufana ne-0.5%). Ngalesi sikhathi, ukusebenzisana phakathi kwama-molecule kubuthakathaka futhi uketshezi luhle. Imvamisa isetshenziswa kuzinhlelo zokusebenza ezifana nezembatho nokukhululwa kwezidakamizwa okulondoloziwe.

Ekugxilisweni okuphezulu: ekugxilweni okuphezulu (okufana nokuphakama okungu-2 Ngalesi sikhathi, uketshezi lwesixazululo lungaphansi kokuphikiswa okukhulu.

I-3. Ubudlelwano phakathi kokuvunywa kanye nokushisa

I-viscosity yekhambi lamanzi le-HPMC lizwela kakhulu izinga lokushisa. Njengoba izinga lokushisa likhuphuka, ukunyakaza phakathi kwama-molecule amanzi kuyanda, futhi ukuxhumana phakathi kwama-molecule we-HPMC kuba buthaka, okuholela ekwehliseni ekuboneni. Lesi sici senza ukusetshenziswa kwe-HPMC emazingeni okushisa ahlukene abonisa ukuguquguquka okuqinile. Isibonelo, ngaphansi kwezimo zokushisa eziphakeme, i-viscosity ye-HPMC ivame ukuncipha, okubaluleke kakhulu kwinqubo yemithi, ikakhulukazi amafomu okukhishwa kwezidakamizwa, lapho kungathinta khona ukuzinza kanye nomphumela wesisombululo.

4. Umphumela we-PH on Viscosity

I-viscosity yesisombululo samanzi se-HPMC nayo ingathinteka ngenani le-PH yekhambi. Yize i-HPMC iyinto engeyona eye-ionic, i-hydrophility yayo kanye nezakhiwo ze-viscosicial zithinteka kakhulu esakhiweni samangqamuzana kanye nemvelo yesixazululo. Kodwa-ke, ngaphansi kwezimo ze-acidic noma ze-alkali noma i-solubity kanye nokwakheka kwamangqamuzana kwe-HPMC kungashintsha, ngaleyo ndlela kuthinte ukubonakala. Isibonelo, ngaphansi kwezimo ze-acidic, i-solubility ye-HPMC ingahle ibe buthaka kancane, okuholele ekuvuselelekeni kwendlela; Ngenkathi ngaphansi kwezimo ze-alkaline, i-hydrolysis yenye i-HPMC ingadala isisindo sayo se-molecular ukuba yehlise, ngaleyo ndlela yehlise ukubonakala kwayo.

5. Isisindo samangqamuzana nokubonakala

Isisindo se-molecular kungenye yezinto ezibalulekile ezithinta ukubonwa kwesisombululo samanzi se-HPMC. Isisindo esiphakeme samangqamuzana sikhulisa ukufakwa kanye nokuxhumanisa phakathi kwama-molecule, okuholela ekutheni kwandiswe ukubonakala. Isisindo esiphansi se-molecular ixyccel®hpmc ine-soubity engcono emanzini kanye nokubonakala okuphansi. Izidingo ezahlukahlukene zesicelo zivame ukudinga ukukhethwa kwe-HPMC ngezinsimbi ezihlukile zamamolekyuli. Isibonelo, kuzimbali kanye nezinamathela, i-High Molecular HPMC ivame ukukhethwa ukunamathela okungcono noketshezi; Ngenkathi usemalungiseleleni amakhambi, i-HPMC ephansi ye-molecular HPMC ingahle isetshenziselwe ukulawula isilinganiso sokukhishwa kwezidakamizwa.

I-6. Ubudlelwano phakathi kwezinga le-Shear kanye ne-Viscosity

I-viscosity yesisombululo esinamanzi e-HPMC ivame ukuguquka ngezinga le-shear, libonisa indlela ejwayelekile ye-pseudoplastic rhelogical yokuziphatha. I-pseudoplastic fluid yi-fluid ene-viscosity yayo enciphisa kancane kancane ngokwanda kwezinga le-shear. Lesi simo senza ikhambi le-HPMC ligcine ukubonwa okuphezulu ngezinga eliphansi le-shear uma kufakwa, futhi kuthuthukisa uketshezi olusezingeni eliphakeme le-shear. Isibonelo, emkhakheni we-Coating, isixazululo se-HPMC sivame ukukhombisa ukubonakala okuphezulu ngesilinganiso esisezingeni eliphansi lapho sifaka isicelo sokuqinisekisa ukunamathela, ngenkathi ngesikhathi sokwakha, kuyadingeka ukukhulisa izinga le-shear ukwenza kungamanzi ngaphezulu.

7. Izici zokusebenzisa kanye ne-viscosity ze-HPMC

Izici ze-Viscosity zeI-HPMCKwenze kusetshenziswe kabanzi emikhakheni eminingi. Isibonelo, embonini yezemithi, i-HPMC ivame ukusetshenziswa njenge-ejenti yokukhishwa kwezidakamizwa, futhi umthetho wayo we-viscoyity isetshenziselwa ukulawula isilinganiso sokukhishwa kwesidakamizwa; Embonini yezokwakha, i-HPMC isetshenziswa njengomuntu omkhulu ukwenza ngcono ukuzokwenza kanye noketshezi lodaka kanye nama-adhesives; Embonini yokudla, i-HPMC ingasetshenziswa njengesikhulu, i-emulsifier ne-stabilizer ukuthuthukisa ukunambitheka nokubukeka kokudla.

Izici ze-Viscosity ze-DiscConche®HPMC Ikhambi elinamanzi ziyisihluthulelo sohlelo lwayo emikhakheni ehlukene. Ukuqonda ubudlelwano balo nezici ezifana nokuhlushwa, izinga lokushisa, i-pH, isisindo kanye nesisindo se-shear kubaluleke kakhulu ekwakheni ukusebenza komkhiqizo kanye nokwenza ngcono uhlelo lokusebenza.