Hlobo luni lwe-polymer yi-HPMC?

I-Hydroxypropyl Methylcellulose (HPMC) iyinhlangano eguquguqukayo ethola izinhlelo ezibanzi ezisetshenziselwa izimboni ezahlukahlukene, kufaka phakathi amakhemikhali, ukudla, ukwakhiwa kanye nezimonyo.

1. Isingeniso ku-HPMC:

I-Hydroxypropyl Methylcellulose (HPMC) yi-semi-zokwenziwa, inert, i-viscoelastic polymer etholakala ku-cellulose. Kwenziwa ngokuguqulwa kwamakhemikhali kwe-cellulose, okubandakanya ukuhanjiswa kwe-Alkali Cellulose nge-propelene oxide ne-methyl chloride. Umkhiqizo ophumayo uwumhlophe omhlophe ophikisayo, onephunga, futhi ongenamsoco okuncibilikayo emanzini kodwa akwehlise ama-solvents ezi-organic.

2. Ukwakheka kanye nezakhiwo:

Isakhiwo sikaHPMC siqukethe umgogodla we-cellulose, i-polymer yemvelo eyenziwe ngama-glucose amayunithi axhumene ne-β (1 → 4) amabhondi e-glycosidic. Ku-HPMC, amanye amaqembu ama-hydroxyl kuma-glucose amayunithi afakwa esikhundleni nge-2-hydroxypropyl kanye namaqembu we-methyl. Lokhu kufakazelwa kwaguqula izakhiwo ze-polymer kuqhathaniswa ne-cellulose yendabuko, ukudlulisela i-solubity ethuthukisiwe, ukuhlakanipha kanye nekhono elenza ifilimu.

Izakhiwo ze-HPMC ziyahlukahluka ngokuya ngezinto ezifana nezinga lokufaka esikhundleni (DS), isisindo se-molecular, kanye nokusatshalaliswa kosayizi wezinhlayiyana. Ngokuvamile, imibukiso ye-HPMC:

Izakhiwo ezinhle kakhulu zefilimu

Ukuziphatha okushisayo kwe-gelelation

Umthamo ophakeme wokugcina amanzi

Ukuqina ngaphezulu kwebanga le-pH elibanzi

Ukuhambisana namanye ama-polymers kanye nezithasiselo

Imvelo okungeyona eye-ionic, okwenza ukuthi ihambisane nezithako ezahlukahlukene

3. Synthesis we-HPMC:

Ukuhlanganiswa kwe-HPMC kufaka izinyathelo eziningana:

Ulungiselelwa i-Alkali Cellulose: I-Celsulose iphathwa ngesisombululo se-Alkaline sokwenza i-Alkali Cellulose.

Ukuthembela: I-Alkali Cellulose iphendula nge-propelene oxide kanye ne-methyl chloride ukwethula i-hydroxypropyl kanye namaqembu we-methyl ku-cellulose backbone.

Ukugeza kanye nokuhlanza: Umkhiqizo ophumelelayo uyagezwa, ungathathi hlangothi, futhi uhlanzwa ukususa ukungcola.

Ukomisa: I-HPMC ehlanziwe yomiswa ukuthola umkhiqizo wokugcina ngefomu le-powder.

4. Izicelo ze-HPMC:

I-HPMC ithola izinhlelo zokusebenza ezisakazekile kuyo yonke imboni ehlukahlukene:

Izemithi: I-HPMC isetshenziswa kabanzi njenge-excipietietical ye-Pharmaceutical Executieutical Exeputient kuma-tablet coatings, ukwakheka okulawulwa okulawulwayo, amalungiselelo we-ophthalmic, kanye nokumiswa. Isebenza njenge-binder, isikhungo, i-ejenti yangaphambili yefilimu, ne-ejenti yokukhishwa kwe-destaged ngezindlela ezahlukahlukene zamadosamu.

Imboni yokudla: Embonini yokudla, i-HPMC isetshenziswa njengesikhudlwana, i-Stabilizer, e-Emulsifier, kanye nomswakama umswakama emikhiqizweni efana nezimpahla ezibhakiwe, imikhiqizo yobisi, amasoso kanye nama-dessert. Kuthuthukisa ukuthungwa, impilo yeshelufu, kanye nomlomo okhalweni emikhiqizweni yokudla.

Ukwakhiwa: I-HPMC isithako esiyisihluthulelo sezinto zokwakha ezifana nodaka osuselwa kusawokujula, izinamathiseli ze-tile, kanye nemikhiqizo esekwe ku-gypsum. Isebenza njenge-ejenti yokugcinwa kwamanzi, ithuthukisa ukusebenziseka, yehlisa ukugcwala, futhi ithuthukise ukunamathela ekwakhekeni kokwakha.

Izimonyo: I-HPMC isetshenziswa kwizimonyo kanye nemikhiqizo yokunakekelwa komuntu siqu njengomuntu omkhulu, i-stabilizer, ne-ejenti eyakha amafilimu emikhiqizweni efana nokhilimu, ama-lotion, ama-shampoos kanye namajeli. Inika i-viscosity, ithuthukisa ukuthungwa, futhi ihlinzeka ngomuzwa obushelelezi, onganamafutha.

Ezinye izinhlelo: I-HPMC nayo iqashwa ekushicilelweni kwezindwangu, ubumba - ubumba, upende, okokuhlanza, nanjenge-lubricant ezinhlokweni ezahlukahlukene zezimboni.

5. Imibono yesikhathi esizayo nezinselelo:

Isidingo se-HPMC kulindeleke ukuthi siqhubeke ukukhula ngenxa yezindawo zayo eziguquguqukayo kanye nezicelo ezahlukahlukene. Kodwa-ke, izinselelo ezinjengokushintshana ngamanani abonakalayo avumayo ezibonakalayo, izingqinamba zokulawula, kanye nomncintiswano ovela enye ama-pollmers kungathinta amandla emakethe. Imizamo yocwaningo igxile ekuthuthukiseni ukusebenza kwe-HPMC, ukuhlola izindlela zokuhlanganiswa okuzinzile, kanye nokwandisa izinhlelo zayo ezinkambu ezivelayo ezifana ne-biomedicine ne-nanotechnology.

I-Hydroxypropyl Methylcellulose (HPMC) iyi-polymer ebalulekile enobubanzi bezicelo ezinzuzweni eziningi. Isakhiwo saso esiyingqayizivele, izakhiwo, kanye nokuhlanganiswa kwenza kube yisithako esibalulekile emikhakheni, imikhiqizo yokudla, izinto zokwakha, izimonyo, izimonyo kanye nezicelo ezahlukahlukene zezimboni. Njengoba imizamo yocwaningo nentuthuko iyaqhubeka, i-HPMC ilungele ukuhlala isidlali esibalulekile embonini ye-polymer, inikeza izixazululo ezintsha zokuhlangabezana nezidingo zemakethe.