At present, the mature raw materials of plant capsules are mainly hydroxypropyl methylcellulose (HPMC) and pullulan, and hydroxypropyl starch is also used as raw materials.
Since the beginning of the 2010s, HPMC has been applied in the Chinese plant capsule manufacturing industry, and based on its good performance, HPMC hollow capsules have firmly occupied a place in the capsule market, showing strong demand in the past decade increase.
According to industry data, in 2020, the domestic sales volume of hollow hard capsules will be about 200 billion capsules (the pharmaceutical and health product industries combined), of which the sales volume of HPMC capsules will be approximately 11.3 billion capsules (including exports), an increase of 4.2% over 2019. %, accounting for about 5.5%. The non-pharmaceutical industry accounts for 93.0% of the consumption of HPMC capsules in China, and the growth of the health care products industry drives the sales of HPMC capsules.
From 2020 to 2025, the CAGR of HPMC capsules with gelling agents is expected to be 6.7%, which is higher than the growth rate of 3.8% for gelatin capsules. Moreover, the demand for HPMC capsules in the domestic health care products industry is higher than that in the pharmaceutical industry. HPMC capsules can both help with prescription challenges and accommodate the cultural and dietary preferences of consumers around the world. Although the current demand for HPMC capsules is still much lower than that of gelatin capsules, the growth rate of demand is higher than that of gelatin capsules.
1) Breakthrough formulation and process, without gelling agent; it has better solubility, consistent dissolution behavior in different media, not affected by pH and ionic strength, and meets the pharmacopoeia requirements of major countries and regions;
2) For weakly alkaline content, improve bioavailability and improve dosage form optimization;
3) The appearance is beautiful, and the color choices are more abundant.
Soft capsule is a preparation formed by sealing oil or oil-based suspension in a capsule shell, and its shape is round, olive-shaped, small fish-shaped, drop-shaped, etc. It is characterized by dissolving or suspending functional ingredients in oil, which has faster onset of action and high bioavailability than making the same functional ingredient into tablets, and has been widely used in the preparation of health care products and medicines. Nowadays, soft capsules with different characteristics such as enteric-coated, chewable, osmotic pump, sustained-release, and soft suppositories are already on the market. The soft capsule shell is composed of colloid and auxiliary additives. Among them, colloids such as gelatin or vegetable gum are the main components, and their quality directly affects the performance of soft capsules. For example, capsule shell leakage, adhesion, material migration, slow disintegration, and dissolution of soft capsules occur during storage Problems such as non-compliance are related to it.
At present, most of the capsule materials of pharmaceutical soft capsules in my country are animal gelatin, but with the in-depth development and application of gelatin soft capsules, its shortcomings and deficiencies have become more prominent, such as complex sources of raw materials, and easy cross-linking reactions with aldehyde compounds Quality problems such as short storage period and the “three wastes” produced in the gelatin refining process have a greater impact on environmental protection. In addition, there is also the problem of hardening in winter, which has a negative impact on the quality of the preparation. And vegetable gum soft capsules have less impact on the surrounding environment. With successive outbreaks of infectious diseases of animal origin all over the world, the international community is increasingly concerned about the safety of animal products. Compared with animal gelatin capsules, plant capsules have outstanding advantages in terms of applicability, safety, stability, and environmental protection.
Add hydroxypropyl methylcellulose to water and disperse to obtain solution A; add gelling agent, coagulant, plasticizer, opacifier and colorant to water and disperse to obtain solution B; mix solutions A and B, and heat up to 90 ~95°C, stir and keep warm for 0.5~2h, cool down to 55~70°C, keep warm and stand for defoaming to get the glue;
How to quickly get the glue liquid, the general process is to heat slowly in a reaction kettle for a long time,
Some manufacturers quickly pass through the colloid mill through chemical glue
Post time: Apr-25-2024