Wholesale hydroxypropyl methylcellulose safety - Pharmaceutical Grade Hydroxypropyl Methylcellulose(HPMC) – Anxin

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Wholesale hydroxypropyl methylcellulose safety - Pharmaceutical Grade Hydroxypropyl Methylcellulose(HPMC) – Anxin Detail:

Product Description

CAS NO.:9004-65-3

Molecular Formula
Hypromellose (Hydroxypropylmethylcellulose: HPMC) substitution type 2910, 2906, 2208 (USP)
Physical Properties
- White or yellowish white powder
- Soluble in mixed organic or aqueous solvent
- Making up transparent film when solvent remove
- No chemical reaction with drug due to its non-ionic property
- Molecular Weight : 10,000 ~ 1,000,000
- Gel point : 40 ~ 90℃
- Auto-ignition Point : 360℃

Hydroxypropyl Methylcellulose (HPMC) Pharmaceutical Grade is Hypromellose pharmaceutical excipient and supplement,which can be used as thickener, dispersant, emulsifier and film-forming agent.

KimaCell Cellulose ether consists of methyl cellulose (USP, EP,BP,CP) and three substitution types of hydroxypropyl methyl cellulose (hypromellose USP, EP,BP,CP) each available in several grades differing in viscosity.HPMC products are derived from natural refined cotton linter and wood pulp, meeting all the requirements of the USP, EP, BP, along with Kosher and Halal Certifications.

In the manufacturing process, highly purified natural cotton is etherified with methyl chloride or with the combination of methyl chloride and propylene oxide to form a water-soluble, non-ionic cellulose ether. No animal resources are used in the production of HPMC.HPMC can be used as a binder for solid dosage forms such as tablets and granules. It also serves a variety of functions, for examples, in enhancing water retention, thickening, acting as a protective colloid due to its surface activity, sustaining release, and film formation.

KimaCell HPMC provides a variety of functions such as water retention, protective colloid, surface activity, sustained release. It is a non-ionic compound resistant to salting out and stable over a wide pH-range. Typical applications of HPMC are binder for solid dosage forms such as tablets and granules or thickener for liquid applications.

Pharma HPMC comes in diverse viscosity ranges from 3 to 200,000 cps, and it can be widely used for tablet coating, granulation, binder, thickener, stabilizer and making vegetable HPMC capsule.

Chemical Specification

Hypromellose Specification	60E ( 2910 )	65F ( 2906 )	75K ( 2208 )
Gel temperature (℃)	58-64	62-68	70-90
Methoxy (WT%)	28.0-30.0	27.0-30.0	19.0-24.0
Hydroxypropoxy (WT%)	7.0-12.0	4.0-7.5	4.0-12.0
Viscosity(cps, 2% Solution)	3, 5, 6, 15, 50, 100, 400,4000, 10000, 40000, 60000,100000,150000,200000

Product Grade

Hypromellose Specification	60E ( 2910 )	65F ( 2906 )	75K ( 2208 )
Gel temperature (℃)	58-64	62-68	70-90
Methoxy (WT%)	28.0-30.0	27.0-30.0	19.0-24.0
Hydroxypropoxy (WT%)	7.0-12.0	4.0-7.5	4.0-12.0
Viscosity(cps, 2% Solution)	3, 5, 6, 15, 50, 100, 400,4000, 10000, 40000, 60000,100000,150000,200000

Application

Pharma Grade HPMC enable the production of controlled-release formulations with the convenience of the most widely used tablet-binding mechanism. Pharma Grade offer good powder flow, content uniformity, and compressibility, making them well suited for direct compression.

Pharma Excipients Application	Pharma Grade HPMC	Dosage
Bulk Laxative	75K4000,75K100000	3-30%
Creams, Gels	60E4000,75K4000	1-5%
Ophthalmic Preparation	60E4000	01.-0.5%
Eye Drops Preparations	60E4000	0.1-0.5%
Suspending Agent	60E4000, 75K4000	1-2%
Antacids	60E4000, 75K4000	1-2%
Tablets Binder	60E5, 60E15	0.5-5%
Convention Wet Granulation	60E5, 60E15	2-6%
Tablet Coatings	60E5, 60E15	0.5-5%
Controlled Release Matrix	75K100000,75K15000	20-55%

Features and Benefits

- Improves product flow characteristics
- Reduces processing times
- Identical, stable dissolution profiles
- Improves content uniformity
- Reduces production costs
- Retains tensile strength after double compaction (roller compaction) process

Packaging

The standard packing is 25kg/drum
20’FCL: 9 ton with palletized; 10 ton unpalletized.
40’FCL: 18 ton with palletized; 20 ton unpalletized.

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HPMC Hydroxypropyl Methyl Cellulose Ether